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2/2018 vol. 68
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In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta
Sylwia Cyboran-Mikołajczyk
,
 
Ákos Csonka
,
 
Joseph Molnar
,
 
Diana Szabó
,
 
Jan Oszmiański
,
 
Halina Kleszczyńska
 
 
 
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Publication date: 2018-06-30
 
 
Pol. J. Food Nutr. Sci. 2018;68(2):171-177
DOI: https://doi.org/10.1515/pjfns-2017-0021
 
 
Article (PDF)
References (28) Citations (6)
 
KEYWORDS
anti-hemolytic activity
cytotoxic activity
L5178Y cells
multidrug resistance
mini-kiwi (Actinidia arguta)
 
ABSTRACT
The leaves of mini kiwi (Actinidia arguta) are a rich source of phenolic compounds, in particular the B-type procyanidins that exhibit e.g. antioxidant, anticancer, antiviral, and anti-inflammatory activities. The aim of this study was to determine the biological activity of the extract from leaves of kiwi in relation to cells of erythrocytes and lymphoma. This activity was determined by studying kiwi leaves extract anti-hemolytic, cytotoxic and antiproliferative activity, and its ability to change the physical properties of the cell membrane and inhibit multidrug resistance of mouse lymphoma cells. It was shown that the extract ingredients bound to the cells, caused changes in erythrocyte shape and slightly affected the granularity and size of lymphoma cells. They effectively protected the red blood cells from oxidative damage, but were not toxic to lymphoma cells and did not affect their multidrug resistance. The extract of kiwi leaves is an effective antioxidant but it does not exhibit cytotoxic activity. Therefore, it can be used in the prevention of diseases, especially those related to oxidative stress.
 
REFERENCES (28)
1.
Akhtar S., Meeran S.M., Katiyar N., Katiyar S.K., Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation and angiogenic factors. Clin. Cancer Res., 2009, 15, 821–831.
Google Scholar
 
 
2.
Becker P.S., Cohen C.M., Lux S.E., The effect of mild diamide oxidation on the structure and function of human erythrocyte spectrin. J. Biol. Chem., 1986, 261, 4620-4628.
Google Scholar
 
 
3.
Bernhardt I., Ellory J.C. (eds.), Membrane lipids and proteins as a basis of red cell shape and its alterations. 2003, in: Red Cell Membrane Transport in Health and Disease. Berlin: Springer-Verlag, pp. 26-60.
Google Scholar
 
 
4.
Bessis M., Erythrocyte form and deformability for normal blood and some hereditary hemolytic anemias. Nouv. Rev. Fr. Hematol., 1997, 18, 75-94.
Google Scholar
 
 
5.
Bonarska-Kujawa D., Pruchnik H., Cyboran S., Żyłka R., Oszmiański J., Kleszczyńska H., Biophysical mechanism of the protective effect of blue honeysuckle (Loniceracaerulea L. var. kamtschatica Sevast.) polyphenols extracts against lipid peroxidation of erythrocyte and lipid membranes. J. Membr. Biol., 2012, 247, 611–625.
Google Scholar
 
 
6.
Bonarska-Kujawa D., Cyboran-Mikołajczyk S., Kleszczyńska H., Molecular mechanism of action of chlorogenic acid on erythrocyte and lipid membrane. Mol. Membr. Biol., 2015, 32, 46-54.
Google Scholar
 
 
7.
Borst J.W., Visser N.V., Kouptsova O., Visser A.J.W.G., Oxidation of unsaturated phospholipids in membrane bilayer mixtures in accompanied by membrane fluidity changes. Biochim. Biophys. Acta, 2000, 1487, 61-73.
Google Scholar
 
 
8.
Buchwald H., O'Dea T.J., Menchaca H.J., Michalek V.N., Rohde T.D., Effect of plasma cholesterol on red blood cell oxygen transport. Clin. Exp. Pharmacol. Physiol., 2000, 27, 951-955.
Google Scholar
 
 
9.
Chai W.M., Shi Y., Feng H.L., Xu L., Xiang Z.H., Gao Y.S., Chen Q.X., Structure characterization and anti-tyrosinase mechanism of polymeric proanthocyanidins fractionated from kiwifruit pericarp. J. Agric. Food Chem., 2014, 62, 6382-6389.
Google Scholar
 
 
10.
Chung Y.C., Huang C.C., Chen C.H., Chiang H.C., Chen K.B., Chen Y.J., Liu C.L., Chuang L.T., Liu M., Hsu C.P., Grape-seed procyanidins inhibit the in vitro growth and invasion of pancreatic carcinoma cells. Pancreas, 2012, 41, 447–454.
Google Scholar
 
 
11.
Cyboran S., Oszmiański J., Kleszczyńska H., Modification of the properties of biological membrane and its protection against oxidation by Actinidia arguta leaf extract. ChemBiol. Interact., 2014, 222, 50-59.
Google Scholar
 
 
12.
Fofie C.K., Wansi S.L., Nguelefack-Mbuyo E.P., Atsamo A.D., Watcho P., Kamanyi A., Nole T., Nguelefack T.B., In vitro anti-hyperglycemic and antioxidant properties of extracts from the stem bark of Ceiba pentandra. J. Complement. Integr. Med., 2014, 11, 185–193.
Google Scholar
 
 
13.
Hale J., Winlove C.P., Petrov P.G., Effect of hydroperoxides on red blood cell membrane mechanical properties. Biophys. J., 2011, 101, 1921-1929.
Google Scholar
 
 
14.
He L., Zhao C., Yan M., Zhang L.Y., Xia Y.Z., Inhibition of P-glycoprotein function by procyanidin on blood-brain barrier. Phytother. Res., 2009, 23, 933–37.
Google Scholar
 
 
15.
Kaur R., Kaur J., Mahajan J., Kumar R., Arora S., Oxidative stress-implications, source and its prevention. Environ. Sci. Pollut. Res., 2014, 21, 1599-1613.
Google Scholar
 
 
16.
Kaur M., Mandair R., Agarwal R., Agarwal C., Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells. Nutr. Cancer, 2008, 60 Suppl., 2–11.
Google Scholar
 
 
17.
Montoya C.A., Rutherfurd S.M., Olson T.D., Purba A.S., Drummond L.N., Boland M.J., Moughan P.J., Actinidin from kiwifruit (Actinidia deliciosa cv. Hayward) increases the digestion and rate of gastric emptying of meat proteins in the growing pig. Brit. J. Nutr., 2014, 111, 957–967.
Google Scholar
 
 
18.
Motohashi N., Shirataki Y., Kawase M., Tani S., Sakagami H., Satoh K., Kurihara T., Nakashima H., Mucsi I., Varga A., Molnár J., Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwi fruit extracts. J. Ethnopharmacol., 2002, 81, 357-364.
Google Scholar
 
 
19.
Pinelli P., Romani A., Fierini E., Remorini D., Agati G., Characterization of the polyphenol content in the kiwifruit (Actinidia deliciosa) exocarp for the calibration of a fruit-sorting optical sensor. Phytochem. Anal., 2013, 24, 460-466.
Google Scholar
 
 
20.
Senguttuvan J., Paulsamy S., Karthika K., Phytochemical analysis and evaluation of leaf and root parts of the medicinal herb Hypochaeris radicata L. for in vitro antioxidant activities. Asian Pac. J. Trop. Biomed., 2014, 4 Suppl., S359-67.
Google Scholar
 
 
21.
Sheetz M.P., Singer S.J., Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactions. Proc. Natl. Acad. Sci., 1974, 71, 4457-4461.
Google Scholar
 
 
22.
Suwalsky M., Orellana P., Avello M., Villena F., Sotomayor C.P. Human erythrocytes are affected in vitro by extracts of Ugni molinae leaves. Food Chem. Toxicol., 2006, 44, 1393-1398.
Google Scholar
 
 
23.
Suwalsky M., Orellana P., Avello M., Villena F., Protective effect of Ugni molinae Turcz against oxidative damage of human erythrocytes. Food Chem. Toxicol., 2007, 45, 130-113.
Google Scholar
 
 
24.
Szabó D., Keyzer H., Kaiser H.E., Molnár J., Reversal of multidrug resistance of tumor cells. Anticancer Res., 2000, 20(6B), 4261-4274.
Google Scholar
 
 
25.
Szabó D., Molnár J., The role of stereoselectivity of chemosensitizers in the reversal of multidrug resistance of mouse lymphoma cells. Anticancer Res., 1998, 18(4C), 3039-3044.
Google Scholar
 
 
26.
Valko M., Leibfritz D., Moncol J., Cronin M.T.D., Mazur M., Telser J., Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell. Biol., 2007, 39, 44–84.
Google Scholar
 
 
27.
Zhao B.X., Sun Y.B., Wang S.Q., Duan L., Huo Q.L., Ren F., Li G.F. Grape seed procyanidin reversal of P-glycoprotein associated multi-drug resistance via down-regulation of NF-κB and MAPK/ERK mediated YB-1 activity in A2780/T cells. PLoS One, 2013, 8(8):e71071.
Google Scholar
 
 
28.
Zuo L.L., Wang Z.Y., Fan Z.L., Tian S.Q., Liu J.R., Evaluation of antioxidant and antiproliferative properties of three Actinidia (Actinidia kolomikta, Actinidia arguta, Actinidia chinensis) extracts in vitro. Int. J. Mol. Sci., 2012, 13, 5506–5518.
Google Scholar
 
 
 
CITATIONS (6):
1.
Characteristics and pro-health properties of mini kiwi (Actinidia arguta)
Ewa Baranowska-Wójcik, Dominik Szwajgier
Horticulture, Environment, and Biotechnology
 
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2.
Trends in kiwifruit and byproducts valorization
V. Sanz, L. López-Hortas, M.D. Torres, H. Domínguez
Trends in Food Science & Technology
 
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3.
In silico, in vitro, and in vivo investigation of antioxidant potential and toxicity of ethyl ferulate
de Bomfim, Lira Brito, Abrahão Filho, Oliveira de, da Rolim, de Castro, Sousa de, Dias Tafaela, Melo Rodrigues, Hilzeth Pessôa, Bezerra Maria, Fátima de
Drug and Chemical Toxicology
 
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4.
Recovery of Bioactive Ellagitannins by Ultrasound/Microwave-Assisted Extraction from Mexican Rambutan Peel (Nephelium lappaceum L.)
Luis Estrada-Gil, Juan Contreras-Esquivel, Carolina Flores-Gallegos, Alejandro Zugasti-Cruz, Mayela Govea-Salas, Marco Mata-Gómez, Raúl Rodríguez-Herrera, Juan Ascacio-Valdés
Molecules
 
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5.
GC-MS Analysis of Bioactive Compounds in Methanolic Extracts of Papaver decaisnei and Determination of Its Antioxidants and Anticancer Activities
Ahmed Jabbar, Fuad Abdullah, Kamaran Abdulrahman, Yaseen Galali, Abdullah Sardar, Christophe Hano
Journal of Food Quality
 
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6.
Nontargeted Metabolomic Analysis of Four Different Parts of Actinidia arguta by UPLC-Q-TOF-MSE
Yu-fei Hou, Lu Bai, Sen Guo, Jia-bing Hu, Shan-shan Zhang, Shao-jing Liu, Ying Zhang, Shiming Li, Chi-Tang Ho, Nai-sheng Bai
Food Research International
 
CrossRef
 
 
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W latach 2022-2024 kwartalnik naukowy Polish Journal of Food and Nutrition Sciences realizuje projekt nr RCN/SP/0520/2021/1 finansowany ze środków budżetu państwa – Ministerstwo Edukacji i Nauki w ramach programu „Rozwój czasopism naukowych”. Dofinansowanie wynosi 120 000 zł. W ramach projektu podejmowane są działania zmierzające do podniesienia poziomu praktyk wydawniczych i edytorskich, zwiększenia wpływu czasopism na rozwój nauki oraz utrzymania się czasopism w międzynarodowym obiegu naukowym.

In the years 2022-2024, the scientific quarterly Polish Journal of Food and Nutrition Sciences accomplishes a project no. RCN/SP/0520/2021/1 financed from the state budged – Ministry of Education and Science Republic of Poland in the framework of a program “Development of scientific journals”. The financing amounts to 120,000 PLN. The program aims at improving the level of publishing and editing practices, increasing the impact of scientific journals on science development, and extending the international range of scientific journals.
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