Search for Author, Title, Keyword
Anti-Glycemic and Anti-Hepatotoxic Effects of Mangosteen Vinegar Rind from Garcinia mangostana Against HFD/STZ-Induced Type II Diabetes in Mice
 
More details
Hide details
Publication date: 2018-06-30
 
Pol. J. Food Nutr. Sci. 2018;68(2):163–169
 
KEYWORDS
ABSTRACT
Glucose-induced reactive oxygen species are associated with diabetic hepatotoxicity. This study focuses on anti-glycemic and anti-hepatotoxic effects of mangosteen vinegar rind (MVR) on high-fat diet (HFD) /streptozotocin (STZ) induced diabetic mice. Male ICR mice were given a HFD for five weeks, followed by a single intraperitoneal injection of STZ 30 mg/kgBW except in the normal control group. After five weeks, based on fasting blood glucose, all mice were randomly divided into five groups (n=6), normal control, diabetic control and diabetic groups who were treated with MVR 100, 200 mg/kg BW and Glibenclamide 60 mg/kg BW for one week. After the treatment, glycogen content, oxidative damage (malondialdehyde, MDA), bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT) were measured in liver tissues. We found that treatment with MVR and Glibenclamide to HFD/STZ-induced diabetic mice significantly reduced plasma glucose, plasma and hepatic lipid profile (P<0.05). Increased hepatic glycogen content indicates improvement of insulin sensitivity. Moreover, oxidative damage markers and anti-oxidant activity were ameliorated in MVR- and Glibenclamide-treated groups compared to the diabetic control group. MVR enriched phenolic content (74.67±1.73 mg GAE/g dry weight) and ensured a high antioxidant potential (303.32+20.54 mmol/L TEAC/g dry weight, IC50=391.24±26.42 mmol/L TEAC/g dry weight) acting as hepatoprotective agents against oxidative damage. These findings suggest that MVR possesses potent anti-glycemic and hepatoprotective effects by reducing metabolic markers, oxidative stress markers with an improvement in hepatic glycogen level and anti-oxidant enzyme activities of HFD/STZ-induced type II diabetic mice.
 
REFERENCES (41)
1.
Bennett L.W., Keirs R.W., Peebles E.D., Gerard P.D., Methodologies of tissue preservation and analysis of the glycogen content of the broiler chick liver. Poult. Sci., 2007, 86, 2653-2665.
 
2.
Berdja S., Smail L., Saka B., Neggazi S., Haffaf E., Benazzoug Y., Kacimi G., Boudarene L., Bouguerra S.A., Glucotoxicity induced oxidative stress and inflammation in vivo and in vitro in Psammomys obesus: involvement of aqueous extract of Brassica rapa rapifera. Evid. Based Complement. Altern. Med., 2016, 2016, art. No. 3689208.
 
3.
Bhandari U., Chaudhari H.S., Khanna G., Najmi A.K., Antidiabetic effects of Embelia ribes extract in high fat diet and low dose streptozotocin-induced type 2 diabetic rats. Front Life Sci., 2013, 7, 186-196.
 
4.
Bligh E.G., Dyer W.J., A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol., 1959, 37, 911-917.
 
5.
Bonnefont-Rousselot D., Glucose and reactive oxygen species. Curr. Opin. Clin. Nutr. Metab. Care, 2002, 5, 561-568.
 
6.
Carr T.P., Andresen C.J., Rudel L.L., Enzymatic determination of triglycerides, free cholesterol and total cholesterol in tissue lipid extracts. Clin. Biochem., 1993, 26, 39-42.
 
7.
Ceci R., Valls M.R.B., Durantin G., Dimauro I., Quaranta F., Pittaluga M., Sabatini S., Caserotti P., Parisi P., Parisi A., Caporossia D., Oxidative stress responses to a graded maximal exercise test in older adults following explosive-type resistance training. Redox Biol., 2014, 2, 65–72.
 
8.
Chang W.C., Wu J.S.B., Chen C.W., Kuo P.L., Chien H.M., Wang Y.T., Shen S.C., Protective effect of vanillic acid against hyperinsulinemia, hyperglycemia and hyperlipidemia via alleviating hepatic insulin resistance and inflammation in high-fat diet (HFD)-fed rats. Nutrients, 2015, 7, 9946–9959.
 
9.
Cordero-Herrera I., Martin M.A., Goya L., Ramos S., Cocoa flavonoids protect hepatic cells against high-glucose-induced oxidative stress: relevance of MAPKs. Mol. Nutr. Food Res., 2015, 59, 597-609.
 
10.
Das J., Sil P.C., Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats. Amino Acids., 2012, 43, 1509–1523.
 
11.
Elgawish R.A.R., Rahman H.G.A., Abdelrazek H.M.A., Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis. Toxicol. Rep., 2015, 2, 1149–1156.
 
12.
Gilbert E.R., Fu Z., Liu D., Development of a nongenetic mouse model of type 2 diabetes. Exp. Diab. Res., 2011, 2011, 416254.
 
13.
Goulart M., Batoreu M.C., Rodrigues A.S., Laires A., Rueff J., Lipoperoxidation production and thiol antioxidant in chromium exposed worker. Mutagenesis, 2005, 20, 311-315.
 
14.
Idris A.S., Mekky K.F.H., Abdalla B.E.E., Ali K.A., Liver function tests in type 2 Sudanese diabetic patients. Int. J. Nutr. Metab., 2011, 2, 17-21.
 
15.
Ismail N.S., Protective effects of aqueous extracts of cinnamon and ginger herbs against obesity and diabetes in obese diabetic rat. World J. Dairy Food Sci., 2014, 9, 145-153.
 
16.
Jarukamjorn K., Lao-ong T., Chatuphonprasert W., Diabetic induction in experimental mouse model. Thai Pharm. Health Sci J., 2011, 6, 229-39, [http://ejournals.swu.ac.th/ind...].
 
17.
Kaisoon O., Siriamornpun S., Weerapreeyakul N., Meeso N., Phenolic compounds and antioxidant activities of edible flowers from Thailand. J. Funct. Foods, 2011, 3, 88-99.
 
18.
Kapoor R., Kakkar P., Protective role of morin, a flavonoid, against high glucose induced oxidative stress mediated apoptosis in primary rat hepatocytes. PLoS One, 2012, 7, 41663.
 
19.
Lee L.S., Cho C.W., Hong H.D., Lee Y.C., Choi U.K., Kim Y.C., Hypolipidemic and antioxidant properties of phenolic compound-rich extracts from white ginseng (Panax ginseng) in cholesterol-fed rabbits. Molecules, 2013, 18, 12548-12560.
 
20.
Li X., Xu Z., Jiang Z., Sun L., Ji J., Miao J., Zhang X., Li X., Huang S., Wang T., Zhang L., Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis. Acta Biochim. Biophys. Sin., 2014, 46, 738-748.
 
21.
Lim Y.S., Lee S.S.H., Tan B.C., Antioxidant capacity and antibacterial activity of different parts of mangosteen (Garcinia mangostana Linn.) extracts. Fruits, 2013, 68, 483-489.
 
22.
Liu J., Dong H., Zhang Y., Cao M., Song L., Pan Q., Bulmer A., Adams D.B., Dong X., Wanga H., Bilirubin increases insulin sensitivity by regulating cholesterol metabolism, adipokines and PPARγ levels. Sci. Rep., 2015, 5, 9886.
 
23.
Marklund S., Marklund G., Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem., 1974, 47, 469-474.
 
24.
Masuko T., Minami A., Iwasaki N., Majima T., Nishimura S., Lee Y.C., Carbohydrate analysis by a phenol-sulfuric acid method in microplate format. Anal. Biochem., 2005, 339, 69–72.
 
25.
McCarty M.F., Serum bilirubin may serve as a marker for increased heme oxygenase activity and inducibility in tissues--a rationale for the versatile health protection associated with elevated plasma bilirubin. Med. Hypotheses, 2013, 81, 607-610.
 
26.
Miralles-Linares F., Puerta-Fernandez S., Bernal-Lopez M.R., Tinahones F.J., Andrade R.J., Gomez-Huelgas R., Metformin-induced hepatotoxicity. Diab. Care, 2012, 35, 21.
 
27.
Moore M.C., Coate K.C., Winnick J.J., An Z., Cherrington A.D., Regulation of hepatic glucose uptake and storage in vivo. Adv. Nutr., 2012, 3, 286-294.
 
28.
Nguyen P., Leray V., Diez M., Serisier S., Bloc’h J.L., Siliart B., Dumon H., Liver lipid metabolism. J. Anim. Physiol. Anim. Nutr. (Berl)., 2008, 92, 272-283.
 
29.
Pandey A., Tripathi P., Pandey R., Srivatava R., Goswami S., Alternative therapies useful in the management of diabetes: a systematic review. J. Pharm. Bioallied Sci., 2011, 3, 504–512.
 
30.
Pandey K.B., Rizvi S.I., Plant polyphenols as dietary antioxidants in human health and disease. Oxid. Med. Cell Longev., 2009, 2, 270–278.
 
31.
Phyu M.P., Tangpong J., Neuroprotective effects of xanthone derivative of Garcinia mangostana against lead-induced acetylcholinesterase dysfunction and cognitive impairment. Food Chem. Toxicol., 2014, 70, 151-156.
 
32.
Ramesh B., Sainath S.B., Karuna R., Sreenivasa Reddy S., Manjunatha B., Sudhakara G., Sasi Bhusana Rao B., Saralakumari D., Effect of Commiphora mukul gum resin on hepatic and renal marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart in fructose fed insulin resistant rats. Beni-Suef Univ. J. Basic Appl. Sci., 2015, 4, 269-278.
 
33.
Re R., Pellegrini N., Proteggente A., Pannala A., Yang M., Rice-Evans C., Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic. Biol. Med., 1999, 26, 1231-1237.
 
34.
Sattayasai J., Chaonapan P., Arkaravichie T., Soi-ampornkul R., Junnu S., Charoensilp P., Samer J., Jantaravinid J., Masaratana P., Suktitipat B., Manissorn J., Thongboonkerd V., Neungton N., Moongkarndi P., Protective effects of mangosteen extract on H2O2-induced cytotoxicity in SK-N-SH cells and scopolamine-induced memory impairment in mice. PLoS One, 2013, 8, 85053.
 
35.
Sherwin R.S., Role of liver in glucose homeostasis. Diab. Care, 1980, 3, 261-265.
 
36.
Sivakrishnan S., Kottaimuthu A., Hepatoprotective activity of ethanolic extract of aerial parts of Albizia procera roxb (Benth.) against paracetamol induced liver toxicity on wistar rats. Int. J. Pharm. Sci., 2014, 6, 233-238.
 
37.
Suriyamoorthy P., Mary M.R.F., Subrhamanian H., Kanagasapabathy D., Protective activity of aqueous leaf extracts of Aegle marmelos and Camellia sinensis in oil induced dyslipidemic rats. World J. Pharm. Sci., 2014, 3, 1568-1580.
 
38.
Takahara S., Hamilton H.B., Nell J.V., Kobra T.Y., Ogura Y., Nishimura E.T., Hypocatalasemia: a new genetic carrier state. J. Clin. Invest., 1960, 39, 610–619.
 
39.
Van den Berghe G., Wilmer A., Hermans G., Meersseman W., Wouters P.J., Milants I., Van Wijngaerden E., Bobbaers H., Bouillon R., Intensive insulin therapy in the medical ICU N. Engl. J. Med., 2006, 354, 449-461.
 
40.
Wilcox G., Insulin and insulin resistance. Clin. Biochem. Rev., 2005, 26, 19-39.
 
41.
World Health Organization (WHO), Global report on diabetes (Diabetes Mellitus-epidemiology), 2016, Geneva.
 
 
CITATIONS (15):
1.
Mangosteen Vinegar Rind from Garcinia mangostana Prevents High‐Fat Diet and Streptozotocin‐Induced Type II Diabetes Nephropathy and Apoptosis
Naymul Karim, Atiar Rahman, Lanchakon Chanudom, Montakarn Thongsom, Jitbanjong Tangpong
Journal of Food Science
 
2.
Recent updates on metabolite composition and medicinal benefits of mangosteen plant
Wan Aizat, Ili Jamil, Faridda Ahmad-Hashim, Normah Noor
PeerJ
 
3.
Short-Time Administration of Xanthone From Garcinia mangostana Fruit Pericarp Attenuates the Hepatotoxicity and Renotoxicity of Type II Diabetes Mice
Naymul Karim, Md. Rahman, Suksan Changlek, Jitbanjong Tangpong
Journal of the American College of Nutrition
 
4.
The effect of Garcinia mangostana L rind ethanol extract on transminase liver enzymes and Bilirubin on liver fibrosis rat model
Triyanta Pramana, Bambang Poerwanto, Suroto, Ambar Mudigdo
INTERNATIONAL CONFERENCE ON SCIENCE AND APPLIED SCIENCE (ICSAS) 2019
 
5.
Biological properties in relation to health promotion effects of Garcinia mangostana (queen of fruit)
Naymul Karim, Jitbanjong Tangpong
Journal of Health Research
 
6.
Tithonia diversifolia aqueous fraction plays a protective role against alloxan-induced diabetic mice via modulating GLUT2 expression
Lanchakon Chunudom, Montakarn Thongsom, Naymul Karim, Md. Rahman, Mohammad Rana, Jitbanjong Tangpong
South African Journal of Botany
 
7.
Cytotoxicity and Toxicity Evaluation of Xanthone Crude Extract on Hypoxic Human Hepatocellular Carcinoma and Zebrafish (Danio rerio) Embryos
Shazrul Fazry, Muhammad Noordin, Salahuddin Sanusi, Mahanem Noor, Wan Aizat, Azwan Lazim, Herryawan Dyari, Nur Jamar, Juwairiah Remali, Babul Othman, Douglas Law, Nik Sidik, Yew Cheah, Yi Lim
Toxics
 
8.
Liposomal delivery of natural product: A promising approach in health research
Shishir Islam, Naymul Karim, Vemana Gowd, Xiaodong Zheng, Wei Chen
Trends in Food Science & Technology
 
9.
The Antidiabetic and Antinephritic Activities of Auricularia cornea (An Albino Mutant Strain) via Modulation of Oxidative Stress in the db/db Mice
Di Wang, Xue Jiang, Shanshan Teng, Yaqin Zhang, Yang Liu, Xiao Li, Yu Li
Frontiers in Immunology
 
10.
SİRKENİN SAĞLIK ÜZERİNE ETKİLERİ
ÇAĞLAR GÖKIRMAKLI, Zeynep Guzel-Seydim, Havva BUDAK
GIDA / THE JOURNAL OF FOOD
 
11.
Mulberry Fruit Extract Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) through Inhibition of Mitochondrial Oxidative Stress in Rats
Dong Yang, Dong-Gyu Jo
Evidence-Based Complementary and Alternative Medicine
 
12.
Garcinia mangostana peel extracts exhibit hepatoprotective activity against thioacetamide-induced liver cirrhosis in rats
Walaa Abood, Sarwan Bradosty, Faiyaz Shaikh, Nur'Ain Salehen, Reyhaneh Farghadani, Nabaz Agha, Morteta Al-Medhtiy, Treska Kamil, Ali Agha, Mahmood Abdulla
Journal of Functional Foods
 
13.
Glucosamine Ameliorates Symptoms of High-Fat Diet-Fed Mice by Reversing Imbalanced Gut Microbiota
Xubing Yuan, Junping Zheng, Lishi Ren, Siming Jiao, Cui Feng, Yuguang Du, Hongtao Liu
Frontiers in Pharmacology
 
14.
Mangosteen Hinders Gamma Radiation-Mediated Oxidative Stress and Liver Injury by Down-Regulating TNF-α/NF-κB and Pro-Fibrotic Factor TGF-β1 Inducing Inflammatory Signaling
Asmaa Hassan, Enas Moustafa, Iman EL-Khashab, Somaya Mansour
Dose-Response
 
15.
Anti-obesity effects of Grifola frondosa through the modulation of lipid metabolism via ceramide in mice fed a high-fat diet
Xue Jiang, Jie Hao, Zijian Liu, Xueting Ma, Yuxin Feng, Lirong Teng, Yu Li, Di Wang
Food & Function
 
eISSN:2083-6007
ISSN:1230-0322