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ORIGINAL ARTICLE
Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity
1
Department of Pharmacognosy, University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11322 Belgrade, Serbia
2
Department of Organic Chemistry, Faculty of Technology, University of Niš, Bulevar Oslobođenja 124, 16000 Leskovac, Serbia
3
Institute of Public Health of Serbia “Dr Milan Jovanovic Batut”, dr Subotića 5, 11000 Belgrade, Serbia
4
Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 11, 11000 Belgrade, Serbia
5
Institute of Public Health Kragujevac, Nikole Pašića 1, 34000 Kragujevac, Serbia
Submission date: 2021-11-01
Final revision date: 2022-05-03
Acceptance date: 2022-05-09
Online publication date: 2022-06-06
Publication date: 2022-06-06
Corresponding author
Tatjana Kundakovic-Vasović
Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Belgrade, Belgrade, Serbia
Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Belgrade, Belgrade, Serbia
Pol. J. Food Nutr. Sci. 2022;72(2):171–181
KEYWORDS
TOPICS
Gas chromatographyLiquid chromatographyMushroomsDietary fiberFlavours/AromasPhenolic compoundsVitamins
ABSTRACT
Nutritional value and chemical composition, including the content of vitamins, fatty acids, 5’-nucleotides and nucleosides and amino acids, as well as biological activities, including antioxidant, angiotensin converting enzyme (ACE) inhibitory and cytotoxic activity of black trumpet (Craterellus cornucopioides (L.) Pers.) were tested in vitro. C. cornucopioides was low in energy, fat and carbohydrate contents, but rich in dietary fibre, especially β-glucan as well as niacin and α-tocopherol. The content of essential and non-essential free amino acids was 1.49 and 5.48 mg/g dry weight (dw). The nucleosides and 5’-nucleotides were determined at 1.84 and 3.99 mg/g dw, respectively. The share of unsaturated fatty acids (UFAs) was 75.92% with oleic acid as the major UFA. Cyclohexane and dichloromethane extracts expressed significant cytotoxic activity against selected cell lines, human epithelial cervical cancer cells (HeLa), adenocarcinomic human alveolar basal epithelial cells (A549), colorectal cancer cells (LS174) and normal MRC-5 human embryonic lung fibroblast cells (IC50 of 78.3–155.6 μg/mL). ACE inhibitory activity of the aqueous extract was strong with an IC50 of 0.74 μg/mL. It can be concluded that black trumpet is a good source of nutrients, such as vitamins, dietary fibres, amino acids, nucleotides and fatty acids, which contribute to the overall nutritional value of this fungus with potential for ACE inhibitory activity and use in anti-hypertensive diet.
FUNDING
This research was funded by the Ministry of Education, Science and Technological Development, Republic of Serbia through Grant Agreement with University of Belgrade-Faculty of Pharmacy No: 451-03-9/2021-14/200161.
CONFLICT OF INTEREST
The authors confirm that this article content has no conflict of interest.
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