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Blood Glucose Lowering Efficacy of Strawberry Extracts rich in Ellagitannins with Different Degree of Polymerization in Rats
 
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Publication date: 2016-06-30
 
Pol. J. Food Nutr. Sci. 2016;66(2):109–117
 
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ABSTRACT
In two experiments on rats it was analysed whether the lowering rate of postprandial glycaemia depends on the degree of polymerization of strawberry ellagitannins (ET). Two types of highly-concentrated polyphenolic extracts were used, one rich in monomeric ET (ETM; 94.9% polyphenols and 67% ETM in it), the second in dimeric ET (ETD; 95.9% polyphenols, and 78.0% ETD in it). The experiment 1 comprised three oral sugar tolerance tests, GTT (with glucose; to examine monosaccharide transport across epithelium), SuTT (with sucrose; to examine the activity of mucosal disaccharidase) and StTT (with starch; to examine the action of salivary alpha-amylase, and then of pancreatic amylase in the small intestine as well as all the aforementioned mechanisms), while in the experiment 2 the healthy and pre-diabetic rats were subjected to 1-h small intestine perfusion with fluids containing glucose or sucrose. Considering the shape of blood glucose concentration curve following GTT and SuTT, as well as changes in glycaemia and mucosal disaccharidases activity observed within and after small intestine perfusion, the ETM (vs ETD) extract more positively mitigated sugar-induced postprandial glycaemic load. Contrary to expectations, the effect of extracts on pre-diabetic rats were negligible. The extract ETD, in turn, potently mitigated starch-induced postprandial glycaemic load during test StTT. The results clearly showed that the separate mechanisms (glucose transport across the intestine, intestinal mucosal disaccharidases inhibition activity, pancreatic α-amylase inhibitory activity) leading to decreased postprandial glycaemia upon dietary administration of strawberry ellagitannins largely depend on their chemical structure, i.e. degree of polymerization.
 
CITATIONS (5):
1.
Protective Effects of Ellagitannin-Rich Strawberry Extracts on Biochemical and Metabolic Disturbances in Rats Fed a Diet High in Fructose
Bartosz Fotschki, Jerzy Juśkiewicz, Krzysztof Kołodziejczyk, Adam Jurgoński, Monika Kosmala, Joanna Milala, Katarzyna Ognik, Zenon Zduńczyk
Nutrients
 
2.
Ellagitannins from Strawberries with Different Degrees of Polymerization Showed Different Metabolism through Gastrointestinal Tract of Rats
Joanna Milala, Monika Kosmala, Elżbieta Karlińska, Jerzy Juśkiewicz, Zenon Zduńczyk, Bartosz Fotschki
Journal of Agricultural and Food Chemistry
 
3.
Agrimoniin, an Active Ellagitannin from Comarum palustre Herb with Anti-α-Glucosidase and Antidiabetic Potential in Streptozotocin-Induced Diabetic Rats
Nina Kashchenko, Nadezhda Chirikova, Daniil Olennikov
Molecules
 
4.
Grinding levels of raspberry pomace affect intestinal microbial activity, lipid and glucose metabolism in Wistar rats
Bartosz Fotschki, Jerzy Juśkiewicz, Adam Jurgoński, Monika Kosmala, Joanna Milala, Zenon Zduńczyk, Jarosław Markowski
Food Research International
 
5.
Ellagic acid in strawberry (Fragaria spp.): Biological, technological, stability, and human health aspects
Selva Muthukumaran, Carole Tranchant, John Shi, Xingqian Ye, Sophia Xue
Food Quality and Safety
 
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ISSN:1230-0322