Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice
 
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Publication date: 2017-09-30
 
Pol. J. Food Nutr. Sci. 2017;67(3):233–240
 
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ABSTRACT
Green tea and green tea extracts (GTE) are often incorporated into diet intended to weight reduction, although the information about their efficacy in obese individuals is insufficient. The present study was designed to follow up the effect of defined and standardized GTE in mice with obesity induced by monosodium L-glutamate. Obese mice were fed with GTE-supplemented diet in three dosage regimens: 28-day and 3-day intake of 1 g GTE in 1 kg of diet and 28-day intake of 0.1 g GTE in 1 kg of diet. The information on body weight, food intake, oxidation stress parameters in blood and antioxidant enzymes activity in liver and small intestine was obtained. High doses of GTE decreased the specific activities of glutathione reductase and catalase and increase concentrations of malondialdehyde in blood. Specific activities of antioxidant enzymes in the liver and small intestine were not altered after GTE treatment except the decrease of NAD(P)H:quinone oxidoreductase activity. Our results showed that GTE did not affect average body weight and did not markedly improve antioxidant status in glutamate-induced obese mice. Moreover, intake of high doses of GTE made antioxidant defense in obese animals even worse.
 
CITATIONS (2):
1.
Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants
Bautista Hernández, Ayman Mahmoud, Mina Königsberg, Díaz López
Biomedicine & Pharmacotherapy
 
2.
Synergistic, additive, and antagonistic antioxidant effects in the mixtures of curcumin with (−)-epicatechin and with a green tea fraction containing (−)-epicatechin
Adriana Slavova-Kazakova, Michał Janiak, Katarzyna Sulewska, Vessela Kancheva, Magdalena Karamać
Food Chemistry
 
eISSN:2083-6007
ISSN:1230-0322