Search for Author, Title, Keyword
Effect of Quercetin on Bone Mineral Status and Markers of Bone Turnover in Retinoic Acid-Induced Osteoporosis
 
More details
Hide details
Publication date: 2018-06-30
 
Pol. J. Food Nutr. Sci. 2018;68(2):149–162
 
KEYWORDS
ABSTRACT
Retinoic acid-induced osteoporosis (RBM) is one of the most common causes of secondary osteoporosis. This study tested the anti-osteoporetic effect of quercetin in RBM-induced bone loss model (RBM). After 14-day supplementation of 13cRA to induce RBM, rats were administered with quercetin (100 mg/kg) or alendronate (40 mg/kg). We analysed changes in body and uterine weight of animals, femoral geometric characteristics, calcium and phosphorus content, bone weight index, bone hystology, bone mineral density (BMD), markers of bone turnover, lipid peroxidation, glutathione levels and SOD, CAT activity of liver, kidney spleen, and ovary as well as biochemical and haematological variables. In comparison to the control RBM rats, the treatment with quercetin increased bone weight index, BMD, osteocalcin level, femoral geometric characteristics, calcium and phosphorus content in the 13cRA-induced bone loss model. Histological results showed its protective action through promotion of bone formation. According to the results, quercetin could be an effective substitution for alendronate in 13cRA-induced osteoporosis. Good therapeutic potential of quercetin on rat skeletal system is based partly on its antioxidant capacity and estrogenic activity.
 
CITATIONS (13):
1.
The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats
Nada Oršolić, Johann Nemrava, Željko Jeleč, Marina Kukolj, Dyana Odeh, Svjetlana Terzić, Rajko Fureš, Tomica Bagatin, Dinko Bagatin
International Journal of Molecular Sciences
 
2.
Circulating serum level of retinoic acid and hip fractures among postmenopausal women
Xiao-Bin Li, Tao Liu, Lei Fan, Qiang Gao, Qiang Peng, Teng Cai, Li-Min Wang
Journal of the American Geriatrics Society
 
3.
The impact of grape proanthocyanidin extract on dexamethasone-induced osteoporosis and electrolyte imbalance
Nabil Hasona, Abdullah Morsi, Abdullah Alghabban
Comparative Clinical Pathology
 
4.
Island rule and bone metabolism in fossil murines from Timor
Justyna Miszkiewicz, Julien Louys, Robin Beck, Patrick Mahoney, Ken Aplin, Sue O’Connor
Biological Journal of the Linnean Society
 
5.
Effects of soybean isoflavone on metabolism of rat osteoblasts and cytokines in vitro
Minan Lu, Kegong Xie, Ke Huang, Xianzhe Lu, Lu Lu, Yu Shi, Yujin Tang
Journal of Food Science
 
6.
Melatonin prevents bone destruction in mice with retinoic acid–induced osteoporosis
Xudong Wang, Tongzhou Liang, Yuanxin Zhu, Jincheng Qiu, Xianjian Qiu, Chengjie Lian, Bo Gao, Yan Peng, Anjing Liang, Hang Zhou, Xiaoming Yang, Zhiheng Liao, Yongyong Li, Caixia Xu, Peiqiang Su, Dongsheng Huang
Molecular Medicine
 
7.
Effect of Propolis on Diet-Induced Hyperlipidemia and Atherogenic Indices in Mice
Nada Oršolić, Jurčević Landeka, Domagoj Đikić, Dunja Rogić, Dyana Odeh, Vedran Balta, Junaković Perak, Svjetlana Terzić, David Jutrić
Antioxidants
 
8.
Quercetin regulates ERα mediated differentiation of BMSCs through circular RNA
Xiaoyun Li, Rumeng Chen, Xiaotong Lei, Panpan Wang, Xiaofeng Zhu, Ronghua Zhang, Li Yang
Gene
 
9.
Oral Administration of Quercetin or Its Derivatives Inhibit Bone Loss in Animal Model of Osteoporosis
Yue-Yue Huang, Zi-Hao Wang, Li-Hui Deng, Hong Wang, Qun Zheng, Oliveira de
Oxidative Medicine and Cellular Longevity
 
10.
The effect of Cornus mas extract consumption on bone biomarkers and inflammation in postmenopausal women: A randomized clinical trial
Naheed Aryaeian, Fatemehsadat Amiri, Seyedeh Rahideh, Jamileh Abolghasemi, Shima Jazayeri, Afsaneh Gholamrezayi, Manijeh Motevalian, Masoud Solaymani‐Dodaran, Mohsen Taghizadeh, Elaheh Heshmati, Shahnaz Rimaz
Phytotherapy Research
 
11.
Role of polyphenols in the metabolism of the skeletal system in humans and animals – a review
Grzegorz Skiba, Stanisława Raj, Monika Sobol, Paweł Kowalczyk, Eugeniusz Grela
Annals of Animal Science
 
12.
Anti-osteoporosis effect and purification of peptides with high calcium-binding capacity from walnut protein hydrolysates
Xiaodong Sun, Shiyan Ruan, Yongliang Zhuang, Liping Sun
Food & Function
 
13.
Chrysin alleviates alteration of bone-remodeling markers in ovariectomized rats and exhibits estrogen-like activity in silico
Sadiyat Ibrahim, Sanusi Mada, Musa Abarshi, Muhammad Tanko, Sanusi Babangida
Human & Experimental Toxicology
 
eISSN:2083-6007
ISSN:1230-0322