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Evaluation of Mango Byproduct Extracts as Antioxidant against Pb-acetate induced Oxidative Stress and Genotoxicity in Mice
 
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Publication date: 2015-03-31
 
 
Pol. J. Food Nutr. Sci. 2015;65(1):39-47
 
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ABSTRACT
The antioxidant and antiproliferative properties of mango by-products were investigated. This study was carried out to evaluate the protective role of mango peel or kernel defatted extracts against Pb-acetate adverse effects on oxidant/antioxidant status, liver dysfunction biomarkers, histopathological changes and genotoxicity in male mice. Total phenolic content and antioxidant activity of both extracts were evaluated. Two doses of both extracts (50 & 100 mg/kg) were used to evaluate their role against the toxicity of Pb-acetate (500ppm). Mice given mango extracts with Pb-acetate had significantly lower plasma MDA, AST and ALT and higher glutathione than mice given Pb-acetate alone. Mango extracts prevented the histopathological changes in liver induced by Pb-acetate and decreased the cytotoxicity of lead by increasing the ratio of PCE/NCE. Mango extract treatment reduced the DNA damage induced by Pb-acetate in liver as demonstrated by a reduction in micronuclei and decrease in tail length, tail DNA% and olive tail moment. It can be concluded that mango by-product extracts have potential to protect from oxidative stress and genotoxicity of lead.
 
CITATIONS (3):
1.
Handbook of Mango Fruit
Yearul Kabir, Hossain Shekhar, Jiwan Sidhu
 
2.
Fruits Grown in Highland Regions of the Himalayas
Syed Hussain, Bazila Naseer, Tahiya Qadri, Tabasum Fatima, Tashooq Bhat
 
3.
Modeling the influence of extraction parameters on the yield and chemical characteristics of microwave extracted mango (Mangifera indica L.) peel pectin by response surface methodology
Singaram Vellaisamy, Nandhini Ganesan
Preparative Biochemistry & Biotechnology
 
eISSN:2083-6007
ISSN:1230-0322
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