OPIOID PEPTIDES DERIVED FROM MILK PROTEINS
 
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Pol. J. Food Nutr. Sci. 2004;54(Special issue 1s):25–35
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ABSTRACT
This paper is devoted to opioid peptides derived from milk proteins. The evolutionary aspect of the biological activity of proteins and peptides, protein precursors, amino acid sequences of opioid peptides, and their biological activity are presented herein. Attention was also paid to the relationship between the conformation of β-casomorphins, their hydrophobicity and their ability to interact with opioid receptors. The biological function of opioid peptides derived from milk proteins was shown from the nutritional and pharmaceutical points of view. In this context, the gastrointestinal, analgesic, tolerance and dependence, respiratory, cardiovascular, immunomodulatory and allergic effects of opioid peptides are discussed. Finally, the perspectives of the application of opioid peptides derived from milk proteins in nutrition and pharmacy are also presented.
ISSN:1230-0322