THE STUDY ON THERAPEUTIC EFFICACY OF INOSINE PRANOBEX IN CHILDREN.
 
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Pol. J. Food Nutr. Sci. 2004;54(Special issue 2s):33–36
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ABSTRACT
Many studies in vitro and in vivo have shown immunomodulating and antiviral activities of inosine pranobex. The objective of this research was to examine the potential beneficial effects of inosine pranobex (Groprinosin) on the immune system in children with cellular immunodeficiency as a prophylaxis of recurrent infections, mainly of viral origin. Inosine pranobex (50 mg/kg b.w./day) in divided doses was given to the group of 30 children aged 3-15 years for 10 days in 3 following months. Clinical and immunological investigations were carried out before and after the treatment. Statistically significant increase in CD3T lymphocytes number (p=0.02) and in this CD4T lymphocytes number (p=0.02) as well as statistically significant improvement of their function (p=0.005) evaluated with the blastic transformation method were found. These laboratory findings were parallel to clinical benefits.
ISSN:1230-0322