The previous study on rats showed that orally administered bifidobacteria stimulated the specific anti-Salmonella Enteritidis immunoglobulin A response (SE IgA R) in blood serum. The aim of the present study was to examine whether prebiotics and synbiotics could modulate SE IgA R as well. During a 2-week experiment, oligofructose as prebiotic (5% w/w in feed; OF group), and the synergistic sets of OF and Bifidobacterium strains (>10⁹ cells per rat, per day), including B. longum KN29.1, B. longum KNA1, and B. animalis KSp4, as synbiotics (OF+B1, OF+B2, OF+B3 groups, respectively), were administered to rats. Half the animals in each group were challenged orally with S. Enteritidis 458 as bacterial antigen. SE IgA R was determined by direct immunometric ELISA method. In non-infected rats, SE IgA R was slightly but significantly (p<0.05) lower in OF and OF+B1 group, it showed a tendency to increase in OF+B2 group, and it was slightly but significantly higher (p<0.01) in OF+B3 group, in comparison to the control. In Salmonella-infected rats, SE IgA R showed a tendency to increase in OF and OF+B1 groups, and was significantly higher in OF+B2 and OF+B3 groups (both p<0.01) than in the control. Oligofructose alone did not stimulate SE IgA R, whereas synbiotics composed of OF and Bifidobacterium showed slight increase only. The results indicate that prebiotics and probiotics managed pathogenic activity in GI tract using different mechanisms - oligofructose possibly as a receptor analogue for pathogenic bacteria, and bifidobacteria by their immune-stimulating activity. Therefore, the SE IgA R obtained was not the effect of synergistic action of synbiotic components.