Current issue
In press
Archive
About the Journal
Scope
Editorial Board
Indexed
Subscription
Contact
Publication fee
Editorial Policies
Peer Review Policy
For Reviewers
Research Ethics Policy
Plagiarism
Informed Consent Policy
Conflict of Interest Policy
Open Access Policy
Corrections, Retractions and Expressions of Concern
Advertising Policy
Instructions for Authors
News
New IMPACT FACTOR
Volume 70 Authors' Index
Volume 70 Reviewers' Index
Dietary recommendations during the COVID-19 pandemic. Statement of the Committee of Human Nutrition Science of the Polish Academy of Sciences
Our new CiteScore2020 from SCOPUS
June 2021 Issue has just been published
September 2021 issue has just been released
Volume 71's Reviewers Index
Our new Impact Factor and Cite Score
Our new CiteScore2022 from SCOPUS
September 2023 issue has just been published
December 2023 issue has just been published
March 2024 issue has just been published
Volume 73's Reviewers Index
June 2024 issue has just been published
Our new CiteScore2023 from SCOPUS
New IMPACT FACTOR 2023
Editorial Policies
Peer Review Policy
For Reviewers
Research Ethics Policy
Plagiarism
Informed Consent Policy
Conflict of Interest Policy
Open Access Policy
Corrections, Retractions and Expressions of Concern
Advertising Policy
News
New IMPACT FACTOR
Volume 70 Authors' Index
Volume 70 Reviewers' Index
Dietary recommendations during the COVID-19 pandemic. Statement of the Committee of Human Nutrition Science of the Polish Academy of Sciences
Our new CiteScore2020 from SCOPUS
June 2021 Issue has just been published
September 2021 issue has just been released
Volume 71's Reviewers Index
Our new Impact Factor and Cite Score
Our new CiteScore2022 from SCOPUS
September 2023 issue has just been published
December 2023 issue has just been published
March 2024 issue has just been published
Volume 73's Reviewers Index
June 2024 issue has just been published
Our new CiteScore2023 from SCOPUS
New IMPACT FACTOR 2023
ORIGINAL ARTICLE
Protective Effect of the Ethanol Extract from Hericium erinaceus Against Ethanol-Induced Gastric Ulcers
1
Institute of Horticulture, Zhejiang Academy of Agricultural Science, Hangzhou, Zhejiang 310021, China
2
Institute of Fungi, Lishui Academy of Agricultural and Forestry Sciences, Lishui, Zhejiang 323000, China
Submission date: 2021-04-28
Final revision date: 2021-08-23
Acceptance date: 2021-08-24
Online publication date: 2021-09-03
Publication date: 2021-09-03
Corresponding author
Pol. J. Food Nutr. Sci. 2021;71(3):333-341
KEYWORDS
TOPICS
ABSTRACT
The fruiting bodies of Hericium erinaceus have been widely used for the treatment of dyspepsia, chronic gastric ulcers, and enervation. There remains a lack of data on the role of an ethanol extract from H. erinaceus (EEH) on ethanol-induced gastric ulcers. The ethanol-induced experimental gastric injury model was used to evaluate the gastroprotective activity of extracts. Ultra-high performance liquid chromatography-triple quadrupole-time of flight tandem mass spectrometry (UPLC-Triple-TOF-MS) analysis was used to identify the possible compounds present in EEH. Transcriptome sequencing(RNA-seq) and bioinformatics analyses were conducted to reveal the characteristics and molecular mechanism underlying EEH’s protective effect of on gastric tissue injury. Administration of EEH at doses of 0.625, 1.25, and 2.5 g/kg body weight prior to ethanol ingestion dose-dependently inhibited gastric ulcers. EEH also significantly increased superoxide dismutase (SOD) activity and decreased malondialdehyde (MDA) content in the gastric tissue. Twelve compounds from EEH were identified including three diterpene compounds, two heteroterpene compounds, three isoindolinone compounds, one aromatic compound, N-(1-deoxy-D-fructos-1-yl)-L-valine, adenosine, and lumichrome. These compounds promote the inhibition of pathways involved in gastric ulcer formation. The RNA-seq results suggest that EEH indirectly protects the gastric tissue from injury by regulating the cell cycle and biological functions, up-regulating several signal molecules, or activating several proteasome functions. It was concluded that EEH represents a potential therapeutic option to reduce the risk of gastric ulceration.
FUNDING
This research was funded by the New Variety Breeding Project of Science Technology Department of Zhejiang Province (Grant number: 2021C02073).
REFERENCES (36)
1.
Agnihotri, N., Kaur, H., Kaur, N., Sarotra, P. (2007). Role of oxidative stress in lansoprazole-mediated gastric and hepatic protection in Wistar rats. Indian Journal of Gastroenterology, 26(3), 118-121.
2.
Asahara, M., Mushiake, S., Shimada, S., Fukui, H., Kinoshita, Y., Kawanami, C., Watanabe, T., Tanaka, S., Ichikawa, A., Uchiyama, Y., Narushima, Y., Takasawa, S., Okamoto, H., Tohyama, M., Chiba, T. (1996). Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress. Gastroenterology, 111(1), 45-55. https://doi.org/10.1053/gast.1....
3.
Chanda, S., Baravalia, Y., Kaneria, M. (2011). Protective effect of Polyalthia longifolia var. pendula leaves on ethanol and ethanol/HCl induced ulcer in rats and its antimicrobial potency. Asian Pacific Journal of Tropical Medicine, 4(9), 673-679. https://doi.org/10.1016/S1995-....
4.
Chen, Z.G., Bishop, K.S., Tanambell, H., Buchanan, P., Smith, C., Quek, S.Y. (2019). Characterization of the bioactivities of an ethanol extract and some of its constituents from the New Zealand native mushroom Hericium novae-zealandiae. Food & Function, 10, 6633-6643. https://doi.org/10.1039/C9FO01....
5.
El-Maraghy, S.A., Rizk, S.M., Shanin, N.N. (2015). Gastric protective effect of crocin in ethanol-induced gastric injury in rats. Chemical-Biological Interactions, 229, 26-35. https://doi.org/10.1016/j.cbi.....
6.
Friedman, M. (2015). Chemistry, nutrition and health-promoting properties of Hericium erinaceus (Lion’s Mane) mushroom fruiting bodies and mycelia and their bioactive compounds. Journal of Agricultural and Food Chemistry, 63(32), 7108-7123. https://doi.org/10.1021/acs.ja....
7.
Higham, A.D., Bishop, L.A., Dimaline, R., Blackmore C.G., Dobbins, A.C., Varro, A., Thompson, D.G., Dockray, G.J. (1999). Mutations of RegIα are associated with enterochromaffin-like cell tumor development in patients with hypergastrinemia. Gastroenterology, 116(6), 1310-1318. https://doi.org/10.1016/S0016-....
8.
Huang, Y., Zhou, C.H., Dai, H.J., Huang, H.H. (2017). In vitro antioxidant activity of ethanol extract from Hericium erinaceus and its different polar fractions. Science and Technology of Food Industry, 21, 16-20.
9.
Hui, Y., Zhao, S.S., Love, J.A., Ansley, D.M., Chen, D.D.Y. (2012). Development and application of a LC-MS/MS method to quantify basal adenosine concentration in human plasma from patients undergoing on-pump CABG surgery. Journal of Chromatography B, 885-886, 30-36. https://doi.org/10.1016/j.jchr....
10.
Kawagishi, H., Ando, M., Mizuno, T. (1990). Hericenone A and B as cytotoxic principles from the mushroom Hericium erinaceum. Tetrahedron Letter, 31(3), 373-376. https://doi.org/10.1016/S0040-....
11.
Kim, S.P., Kang, M.Y., Kim, J.H., Nam, S.H., Friedman, M. (2011). Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice. Journal of Agricultural and Food Chemistry, 59(18), 9861-9869. https://doi.org/10.1021/jf2019....
12.
Lee, D.G., Kang, H.W., Park, C.G., Ahn, Y.S., Shin, Y. (2016). Isolation and identification of phytochemicals and biological activities of Hericium ernaceus and their contents in Hericium strains using HPLC/UV analysis. Journal of Ethnopharmacology, 184, 219-225. https://doi.org/10.1016/j.jep.....
13.
Li, W., Zhou, W., Kim, E.J., Shim, S.H., Kang, H.K., Kim, Y.H. (2015). Isolation and identification of aromatic compounds in Lion’s Mane mushroom and their anticancer activities. Food Chemistry, 170, 336-342. https://doi.org/10.1016/j.food....
14.
Liu, B., Yili, A., Asia, H.A., Aikemu, M. (2018). Gastroprotective effect of the protease-rich extract from sheep abomasum against stress-induced gastric ulcers in rats. Journal of Food Biochemistry, 42(5), art. no. e12558. https://doi.org/10.1111/jfbc.1....
15.
Liu, J.H., Li, L., Shang, X.D., Zhang, J.L., Tan, Q. (2016). Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus. Journal of Ethnopharmacology, 183, 54-58. https://doi.org/10.1016/j.jep.....
16.
Ma, L., Liu, J.G. (2014). The protective activity of Gonyza blinii saponin against acute gastric ulcer induced by ethanol. Journal of Ethnopharmacology, 158, Part A, 358-363. https://doi.org/10.1016/j.jep.....
17.
Masek, A., Chrzescijanska, E., Zaborski, M., Maciejewska, M. (2012). Characterisation of the antioxidant activity of riboflavin in an elastomeric composite. Comptes Rendus Chimie, 15(6), 524-529. https://doi.org/10.1016/j.crci....
18.
Mei, X., Xu, D., Xu, S., Zheng, Y., Xu, S. (2012). Novel role of Zn (II)-curcumin in enhancing cell proliferation and adjusting proinflammatory cytokine-mediated oxidative damage of ethanol-induced acute gastric ulcers. Chemico-Biological Interactions, 197(1), 31-39. https://doi.org/10.1016/j.cbi.....
19.
Miyazawa, M., Takahashi, T., Horibe, I., Ishikawa, R. (2012). Two new aromatic compounds and a new D-arabinitol ester from the mushroom Hericium erinaceum. Tetrahedron, 68(7), 2007-2010. https://doi.org/10.1016/j.tet.....
20.
O’Malley, P. (2003). Gastric ulcers and CERD: the new “plagues” of the 21st century update for the Clinical Nurse Specialist. Clinical Nurse Specialist, 17(6), 286-289. https://doi.org/10.1097/000028....
21.
Pan, J.S., He, S.Z., Xu, H.Z., Zhan, X.J., Yang, X.N., Xiao, H.M., Shi, H.X., Ren, J.L. (2008). Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury. World Journal of Gastroenterology, 14(38), 5857-5867. https://doi.org/10.3748/wjg.14....
22.
Qin, M., Geng, Y., Lu, Z., Xu, H., Shi, J., Xu, X., Xu, Z. (2016). Anti-inflammatory effects of ethanol extract of Lion’s Mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), in mice with ulcerative colitis. International Journal of Medicinal Mushrooms, 18(3), 227-234. https://doi.org/10.1615/IntJMe....
23.
Ramkumar, V., Nie, Z., Rybak, L.P., Maggirwar, S.B. (1995). Adenosine, antioxidant enzymes and cytoprotection. Trends in Pharmacological Sciences, 16(9), 283-285. https://doi.org/10.1016/S0165-....
24.
Sahin, H., Kaltalioglu, K., Erisgin, Z., Coskun-Cevher, S., Kolayli, S. (2019). Protective effects of aqueous extracts of some honeys against HCl/ethanol-induced gastric ulceration in rats. Journal of Food Biochemistry, 43(12), art. no. e 13054. https://doi.org/10.1111/jfbc.1....
25.
Saiah, W., Halzoune, H., Djaziri, R., Tabani, K., Koceir, E.A., Omari, N. (2018). Antioxidant and gastroprotective actions of butanol fraction of Zingiber officinale against diclofenac sodium-induced gastric damage in rats. Journal of Food Biochemistry, 42(1), art. no. e12456. https://doi.org/10.1111/jfbc.1....
26.
Salim, A.S. (1990). Removing oxygen-derived free radicals stimulates healing of ethanol-induced erosive gastritis in the rat. Digestion, 47(1), 24-28. https://doi.org/10.1159/000200....
27.
Sathish, R., Vyawahare, B., Natarajan, K. (2011). Antiulcerogenic activity of Lantana camara leaves on gastric and duodenal ulcers in experimental rats. Journal of Ethnopharmacology, 134(1), 195-197. https://doi.org/10.1016/j.jep.....
28.
Sreeja, P.S., Arunachalam, K., Saikumar, S., Kasipandi, M., Dhivya, S., Murugan, R., Parimelazhagan, T. (2018). Gastroprotective effect and mode of action of methanol extract of Sphenodesme involucrate var. paniculate (C.B. Clarke) Munir (Lamiaceae) leaves on experimental gastric ulcer models. Biomedicine & Pharmacotherapy, 97, 1109-1118. https://doi.org/10.1016/j.biop....
29.
Tang, H.Y., Yin, X., Zhang, C.C., Jia, Q., Gao, J.M. (2015). Structure diversity, synthesis, and biological activity of cyathane diterpenoids in higher fungi. Current Medicinal Chemistry, 22(19), 2375-2391. https://doi.org/10.2174/092986....
30.
Tsukamoto, S., Kato, H., Hirota, H., Fusetani, N. (1999). Lumichrome, a larval metamorphosis-inducing substance in the ascidian Halocynthia roretzi. European Journal of Biochemistry, 264(3), 785-789. https://doi.org/10.1046/j.1432....
31.
Wang, X.L., Xu, K.P., Long, H.P., Zou, H., Cao, X.Z., Zhang ,K., Hu, J.Z., He, S.J., Zhu, G.Z., He, X.A., Xu, P.S., Tan, G.S. (2016). New isoindolinones from the fruiting bodies of Hericium ernaceum. Fitoterapia, 111, 58-65. https://doi.org/10.1016/j.fito....
32.
Wang, X.Y., Yin, J.Y., Zhao, M.M., Liu, S.Y., Nie, S.P., Xie, M.Y. (2018a). Gastroprotective activity of polysaccharide from Hericium erinaceus against ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer, and its antioxidant activities. Carbohydrate Polymers, 186, 100-109. https://doi.org/10.1016/j.carb....
33.
Wang, Y., Luan, G., Zhou, W., Meng, J., Wang, H., Hu, N., Suo, Y. (2018b). Subcritical water extraction, UPLC-Triple-TOF/MS analysis and antioxidant activity of anthocyanins from Lucium ruhtenicum Murr. Food Chemistry, 249, 119-126. https://doi.org/10.1016/j.food....
34.
Wu, F., Zhou, C., Zhou, D., Ou, S., Zhang, X., Huang, H. (2018). Structure characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its immunomodulatory activities. Food & Function, 9(1), 294-306. https://doi.org/10.1039/C7FO01....
35.
Yaoita, Y., Danbara, K., Kikuchi, M. (2005). Two new aromatic compounds from Hericium erinaceum (Bull.:Fr.) Pers. Chemical & Pharmceutical Bulletin, 53(9), 1202-1203. https://doi.org/10.1248/cpb.53....
36.
Zhao, J., Wang, J., Wang, H., Lai, M. (2013). Chapter Five – Reg proteins and their roles in inflammation and cancer of the human digestive system. Advances in Clinical Chemistry, 61, 153-173. https://doi.org/10.1016/B978-0....
CITATIONS (1):
1.
Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression
Pit Chong, Chi Poon, Jaydeep Roy, Ka Tsui, Sze Lew, Michael Phang, Rachael Tan, Poh Cheng, Man-Lung Fung, Kah Wong, Lee Lim
Chinese Medicine
Pit Chong, Chi Poon, Jaydeep Roy, Ka Tsui, Sze Lew, Michael Phang, Rachael Tan, Poh Cheng, Man-Lung Fung, Kah Wong, Lee Lim
Chinese Medicine
| eISSN: | 2083-6007 |
| ISSN: | 1230-0322 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
