The present research dealt with comparing the effect of zinc-vitamin A-micronutrient mixture (ZAMM) administration on the nutritional status of infants with acute and persistent diarrhea. In addition, its effect on the management of both types of diarrhea was studied . Zinc and vitamin A were given as 8 mg and 751μg retinol equivalent respectively per day. The results showed that administration of ZAMM produced an increase in body weight and a significant increase in haemoglobin concentration in acute and persistent diarrheal cases with a significant increase in mean corpuscular volume in persistent diarrhea cases. Plasma zinc and vitamin A levels showed a significant increase in acute diarrheal infants after supplementation of ZAMM. Certain parameters , reflecting management of diarrhea such as appetite, stool frequency and duration of diarrhea, have been improved after ZAMM supplementation . Conclusion: ZAMM administration improved both nutritional status and diarrheal state in infants with either acute or persistent diarrhea, however its effect was more promising in acute cases.