It is a common opinion that pathologic signs of allergy are connected with the prompt anaphylactic reaction. The knowledge about the so-called late reaction of the response to the allergen is less widespread. In the case of frequent or constant exposure to the allergen of late type, chronic inflammation and irreversible tissue damage appear. It may happen due to the intake of low doses of zearalenone in plant material. Zearalenone in the first period of its activity interferes in the processes of protein synthesis. On the other hand, the presence of environmental estrogens affects feminization of fish, birds and mammals. These xenobiotics, including zearalenone, probably take part in pathological conditions that occur as a result of autoimmunization and allergy. These dysfunctions and pathological conditions are in majority of cases noted more often in females than in males. They are often the primary cause of the induced diseases of the allergic origin like asthma, inflammation of nasal mucosa, skin inflammation and disturbances in the alimentary tract. In addition, environmental estrogens directly influence the immunological system or more probably they indirectly modulate this system through other tissues in order to change the model of cytokines. This study presents the thoughts over the hazards for human and animal health posed by environmental estrogens (especially zearalenone) even in the allergies. In humans the number of the results that would allow for any conclusion is minimal. In this situation, first their influence on the immunological system in animals was considered, then the pathological effect of low doses of the xenobiotic on the immunological system was estimated. It would be recommended to take longer period into account focusing on the results of the possible autoimmunization or allergy.