Search for Author, Title, Keyword
Anticholinesterase Activities of Selected Polyphenols – a Short Report
More details
Hide details
Publication date: 2014-03-31
Pol. J. Food Nutr. Sci. 2014;64(1):59-64
In this work, anticholinesterase activities of 24 polyphenolic compounds were tested using the modified Ellman’s spectrophotometric method. The most efficient acetyl- and butyrylcholinesterase inhibitors were anthocyanins (pelargonidin, delphinidin and cyanidin), flavones (apigenin and luteolin), flavonols (quercetin, kaempferol and myricetin), as well as dihydrochalcone phloridzin and prenylated chalcone xanthohumol. It was established that all the tested compounds were within a narrow molecular weight range of 254.24–354.40 g/mol, which probably was not discriminative for their inhibitory activity. Among all the classes of polyphenolic compounds, the lowest activities were exerted by flavan-3-ols. The inhibitory activity of the tested polyphenols was decreased by the presence of a 3-hydroxyl group. A simultaneous substitution of a carbonyl group at position 4 and a hydroxyl group at position 3 or a lack of both of these substitutions had no effect on the activity of the investigated compounds. The number and position of other hydroxyl groups in the tested molecules played a minor role in this context. Aglycons were more effective cholinesterase inhibitors than their corresponding glycosylated forms. Overall, the results show that phenolic acids can play a role in neuroprotection. However, further in vitro and in vivo studies involving a larger number of polyphenolic compounds simultaneously with well-known cholinesterase inhibitors should be performed in the nearest future to confirm these findings.
Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven Morus spp. Cultivated in Thailand
Piya Temviriyanukul, Varittha Sritalahareuthai, Kriskamol Jom, Butsara Jongruaysup, Somying Tabtimsri, Kanchana Pruesapan, Sirinapa Thangsiri, Woorawee Inthachat, Dalad Siriwan, Somsri Charoenkiatkul, Uthaiwan Suttisansanee
Protective Influence of Phyllanthus Muellarianus on Ciprofloxacin-Induced Neurotoxicity in Male Rats
O. Ibitoye, N. Aliyu, T. Ajiboye
Journal of Dietary Supplements
Genoprotective and neuroprotective effects of Daphne gnidium leaf methanol extract, tested on male mice
Fadwa Chaabane, Imen Mokdad-Bzeouich, Aicha Sassi, Nadia Mustapha, Raja Majouli, Kamel Ghedira, Leila Chekir-Ghedira
Drug and Chemical Toxicology
Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice
Maressa Morzelle, Jocelem Salgado, Milena Telles, Danilo Mourelle, Patricia Bachiega, Hudson Buck, Tania Viel, Madepalli Lakshmana
Phytochemical Analysis, Antioxidant, Antistress, and Nootropic Activities of Aqueous and Methanolic Seed Extracts of Ladies Finger (Abelmoschus esculentusL.) in Mice
Sathish Doreddula, Srinivasa Bonam, Durga Gaddam, Brahma Desu, Nadendla Ramarao, Vijayapandi Pandy
The Scientific World Journal
Dihydrochalcones: Methods of Acquisition and Pharmacological Properties—A First Systematic Review
Monika Stompor, Daniel Broda, Agata Bajek-Bil
Discovery and Development of Neuroprotective Agents from Natural Products
Syed Omar
Comparative biophysical characterization: A screening tool for acetylcholinesterase inhibitors
Devashree Patil, Sushama Patil, Srinivas Sistla, Jyoti Jadhav, David Lightfoot
Phytochemical analysis, molecular docking and antiamnesic effects of methanolic extract of Silybum marianum (L.) Gaertn seeds in scopolamine induced memory impairment in mice
Nausheen Nazir, Nasiara Karim, Heba Abdel-Halim, Imran Khan, Syed Wadood, Muhammad Nisar
Journal of Ethnopharmacology
Biological properties of phenolic compound extracts in selected Algerian honeys—The inhibition of acetylcholinesterase and α-glucosidase activities
Hicham Zaidi, Salim Ouchemoukh, Nadia Amessis-Ouchemoukh, Nadjet Debbache, Rita Pacheco, M. Serralheiro, M. Araujo
European Journal of Integrative Medicine
New dihydrostilbenes from Macaranga heynei I.M. Johnson, biological activities and structure-activity relationship
Aisyah Kamarozaman, Norizan Ahmat, Siti Isa, Zetty Hafiz, Mohd Adenan, Mohd Yusof, Nik Azmin, Jalifah Latip
Phytochemistry Letters
Phenolic profile and biological activity of Hypericum perforatum L.: Can roots be considered as a new source of natural compounds?
O. Tusevski, M. Krstikj, J.P. Stanoeva, M. Stefova, Simic Gadzovska
South African Journal of Botany
Polyphenolic composition, enzyme inhibitory effects ex-vivo and in-vivo studies on two Brassicaceae of north-central Italy
Adriano Mollica, Azzurra Stefanucci, Gokhan Zengin, Marcello Locatelli, Giorgia Macedonio, Giustino Orlando, Claudio Ferrante, Luigi Menghini, Lucia Recinella, Sheila Leone, Annalisa Chiavaroli, Lidia Leporini, Nisio Di, Luigi Brunetti, Eltayeb Tayrab, Islam Ali, Taha Musa, Hassan Musa, Abdelkareem Ahmed
Biomedicine & Pharmacotherapy
Acetylcholinesterase and carbonic anhydrase isoenzymes I and II inhibition profiles of taxifolin
Hulya Gocer, Fevzi Topal, Meryem Topal, Murat Küçük, Dilek Teke, İlhami Gülçin, Saleh Alwasel, Claudiu Supuran
Journal of Enzyme Inhibition and Medicinal Chemistry
In Vitro Antioxidant, Anti-Diabetes, Anti-Dementia, and Inflammation Inhibitory Effect of Trametes pubescens Fruiting Body Extracts
Kyung Im, Trung Nguyen, Jaehyuk Choi, Tae Lee
Phytochemical composition of Caesalpinia crista extract as potential source for inhibiting cholinesterase and β-amyloid aggregation: Significance to Alzheimer's disease
KolambeRajappa Chethana, BalappaSomappa Sasidhar, Mahadeva Naika, RangappaSangappa Keri
Asian Pacific Journal of Tropical Biomedicine
Phytochemical profiles, antioxidant and anti-acetylcholinesterasic activities of the leaf extracts of Rhamnus lycioides subsp. oleoides (L.) Jahand. & Maire in different solvents
Houari Benamar, Elonge Rarivoson, Lamberto Tomassini, Claudio Frezza, Abderrazak Marouf, Malika Bennaceur, Marcello Nicoletti
Natural Product Research
Activity-guided isolation of cholinesterase inhibitors quercetin, rutin and kaempferol from Prunus persica fruit
Dominik Szwajgier, Kamila Borowiec, Josef Zapp
Zeitschrift für Naturforschung C
Chemometric discrimination of three Pistacia species via their metabolic profiling and their possible in vitro effects on memory functions
Bishbishy El, Haidy Gad, Nora Aborehab
Journal of Pharmaceutical and Biomedical Analysis
In vitro multimodal-effect of Trichilia catigua A. Juss. (Meliaceae) bark aqueous extract in CNS targets
João Bernardo, Federico Ferreres, Ángel Gil-Izquierdo, Romeu Videira, Patrícia Valentão, Francisco Veiga, Paula Andrade
Journal of Ethnopharmacology
Phytochemical composition and the cholinesterase and xanthine oxidase inhibitory properties of seed extracts from the Washingtonia filifera palm fruit
Sonia Floris, Antonella Fais, Antonella Rosa, Alessandra Piras, Hanen Marzouki, Rosaria Medda, Ana González-Paramás, Amit Kumar, Celestino Santos-Buelga, Benedetta Era
RSC Advances
Antioxidant Activity and Acetylcholinesterase Inhibition of Grape Skin Anthocyanin (GSA)
Mehnaz Pervin, Md. Hasnat, Yoon Lee, Da Kim, Jeong Jo, Beong Lim
Multidirectional insights on Chrysophyllum perpulchrum leaves and stem bark extracts: HPLC-ESI-MSn profiles, antioxidant, enzyme inhibitory, antimicrobial and cytotoxic properties
Mehmet Baloglu, Eulogio Llorent-Martínez, Muhammad Aumeeruddy, Mohamad Mahomoodally, Yasemin Altunoglu, Buket Ustaoglu, Mustafa Ocal, Songül Gürel, Kouadio Bene, Kouadio Sinan, Gokhan Zengin
Industrial Crops and Products
Investigation of Antioxidant and Anticholinesterase Potential of Essential Oil and Methanolic Extract of Propolis from Mila Region
Safia Boulechfar, Amar Zellagui, Ahmed Chemsa, Chawki Bensouici, Narimane Segueni, Mesbah Lahouel, Mehmet Öztürk, Mehmet Duru
Journal of Biologically Active Products from Nature
Characterization in vitro potency of biological active fractions of seeds, skins and flesh from selected Vitis vinifera L. cultivars and interspecific hybrids
Karolina Tkacz, Aneta Wojdyło, Paulina Nowicka, Igor Turkiewicz, Tomasz Golis
Journal of Functional Foods
Mulberry Fruit Cultivar ‘Chiang Mai’ Prevents Beta-Amyloid Toxicity in PC12 Neuronal Cells and in a Drosophila Model of Alzheimer’s Disease
Uthaiwan Suttisansanee, Somsri Charoenkiatkul, Butsara Jongruaysup, Somying Tabtimsri, Dalad Siriwan, Piya Temviriyanukul
Molecular docking and antiamnesic effects of nepitrin isolated from Rosmarinus officinalis on scopolamine-induced memory impairment in mice
Nasiara Karim, Imran Khan, Abeer Abdelhalim, Heba Abdel-Halim, Jane Hanrahan
Biomedicine & Pharmacotherapy
Anticholinergic effects of Actinidia arguta fruits and their polyphenol content determined by liquid chromatography-photodiode array detector-quadrupole/time of flight-mass spectrometry (LC-MS-PDA-Q/TOF)
Aneta Wojdyło, Paulina Nowicka
Food Chemistry
Phytochemical analysis of Viburnum davidii Franch. and cholinesterase inhibitory activity of its dihydrochalcones
Lamberto Tomassini, Antonio Ventrone, Claudio Frezza, Anna Fabbri, Stefano Fortuna, Maria Volpe, Maria Cometa
Natural Product Research
Dual electrophoretically-mediated microanalysis in multiple injection mode for the simultaneous determination of acetylcholinesterase and α-glucosidase activity applied to selected polyphenols
Diogo Siebert, Juliana Campos, Michele Alberton, Luciano Vitali, Gustavo Micke
Phenolic Profiles of Hardy Kiwifruits and Their Neuroprotective Effects on PC-12 and SH-SY5Y Cells against Oxidative Stress
Ha-Ram Jeong, Kwan Kim, Sang Lee, Hye Cho, Youn-Sup Cho, Dae-Ok Kim
Journal of Microbiology and Biotechnology
Anticholinesterase Activities of Different Solvent Extracts of Brewer’s Spent Grain
Rares Birsan, Peter Wilde, Keith Waldron, Dilip Rai
LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure
Łukasz Świątek, Elwira Sieniawska, Kouadio Sinan, Magdalena Maciejewska-Turska, Anastazja Boguszewska, Małgorzata Polz-Dacewicz, Ismail Senkardes, Gokalp Guler, Sadeer Bibi, Mohamad Mahomoodally, Gokhan Zengin
International Journal of Molecular Sciences
Phenolic acids and flavonoids‐rich Glechoma hederacea L. (Lamiaceae) water extract against H 2 O 2 ‐induced apoptosis in PC12 cells
Wen‐Wan Chao, Wan‐Ching Chan, Hao‐Ting Ma, Su‐Tze Chou
Journal of Food Biochemistry
Neuroprotective effects of Lippia javanica (Burm.F.) Spreng. Herbal tea infusion on Lead-induced oxidative brain damage in Wistar rats
Zubair Suleman, Godwill Engwa, Mathulo Shauli, Hannibal Musarurwa, Ndinashe Katuruza, Constance Sewani-Rusike
BMC Complementary Medicine and Therapies
Biological Activity of Extracts of Red and Yellow Fruits of Cornus mas L.—An In Vitro Evaluation of Antioxidant Activity, Inhibitory Activity against α-Glucosidase, Acetylcholinesterase, and Binding Capacity to Human Serum Albumin
Olha Dzydzan, Iryna Brodyak, Paulina Strugała-Danak, Angelika Strach, Alicja Kucharska, Janina Gabrielska, Natalia Sybirna
Polyphenols composition and the biological effects of six selected small dark fruits
Kamila Borowiec, Anna Stachniuk, Dominik Szwajgier, Alicja Trzpil
Food Chemistry
Honeys as Possible Sources of Cholinesterase Inhibitors
Dominik Szwajgier, Ewa Baranowska-Wójcik, Anna Winiarska-Mieczan, Dorota Gajowniczek-Ałasa
Antihypertensive Activity in High Salt-Induced Hypertensive Rats and LC-MS/MS-Based Phytochemical Profiling of Melia azedarach L. (Meliaceae) Leaves
Anam Saeed, Kashif Bashir, Abdul Shah, Rahila Qayyum, Taous Khan, Abdul Wahab
BioMed Research International
Discovery of Potent and Selective Dual Cholinesterases and β-Secretase Inhibitors in Pomegranate as a Treatment for Alzheimer’s Disease
Ali Yousof, Sumera Zaib, Susoma Jannat, Imtiaz Khan
Bioorganic Chemistry
Effects of microwave and exogenous l-phenylalanine treatment on phenolic constituents, antioxidant capacity and enzyme inhibitory activity of Tartary buckwheat sprouts
Wenping Peng, Nan Wang, Shunmin Wang, Junzhen Wang, Zixiu Bian
Food Science and Biotechnology
Phytochemical screening, biological evaluation, anatomical, and morphological investigation of Ferula tingitana L. (Apiaceae)
Songül Karakaya, Hafize Yuca, Gülderen Yılmaz, Bilge Aydın, Enes Tekman, Gülnur Ekşi, Mehmet Bona, Gamze Göger, Mehmet Karadayı, Yusuf Gülşahin, Gözde Öztürk, Betül Demirci, Zühal Güvenalp
Phenolic profiles and acetylcholinesterase inhibitory activity in Australian adzuki bean
Joel Johnson, Pasmita Neupane, Surya Bhattarai, Tieneke Trotter, Mani Naiker
Food Chemistry Advances
Malvidin and Its Mono- and Di-Glucosides Forms: A Study of Combining Both In Vitro and Molecular Docking Studies Focused on Cholinesterase, Butyrylcholinesterase, COX-1 and COX-2 Activities
Paulina Strugała-Danak, Maciej Spiegel, Janina Gabrielska
Flavonols as a Potential Pharmacological Intervention for Alleviating Cognitive Decline in Diabetes: Evidence from Preclinical Studies
Anđela Horvat, Ignacija Vlašić, Jasminka Štefulj, Nada Oršolić, Jembrek Jazvinšćak
Comparative assessment of phenolic composition profile and biological activities of green extract and conventional extracts of Salvia sclarea
Mohammed Mansour Quradha, Mehmet Emin Duru, Selcuk Kucukaydin, Alfred Ngenge Tamfu, Mudassar Iqbal, Hamida Bibi, Rasool Khan, Ozgur Ceylan
Scientific Reports
From the chokeberry fruit products and by-products to health-promoting effects through multifaceted in vitro bioactivity evaluation and molecular docking studies
Milica Milutinović, Nada Ćujić Nikolić, Milica Radan, Tatjana Mihajilov Krstev, Katarina Šavikin, Predrag Petrović, Milica Randjelović, Bojana Miladinović, Suzana Branković, Dušanka Kitić
Journal of Berry Research
Journals System - logo
Scroll to top