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Coffee and its Biologically Active Components: Is There a Connection to Breast, Endometrial, and Ovarian Cancer? - a Review
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Department of Food Biotechnology, Faculty of Health Sciences, Medical University, Szpitalna 37, 15-295 Białystok, Poland
Submission date: 2019-12-11
Final revision date: 2020-04-01
Acceptance date: 2020-04-02
Online publication date: 2020-05-25
Publication date: 2020-05-25
Corresponding author
Anna Maria Witkowska   

Department of Food Biotechnology, Medical University, Szpitalna 37, 15-295, Bialystok, Poland
Pol. J. Food Nutr. Sci. 2020;70(3):207-222
Coffee is an important dietary source of biologically active components, not to mention caffeine, phenolic acids, and diterpenes. It has been suggested that selected coffee secondary metabolites may beneficially modulate several mechanisms of anti-cancer protection. This literature review was intended to present current knowledge related to coffee and its components and hormone-dependent female cancers, such as breast, endometrial and ovarian cancer, and to identify gaps in research that may be exploited in the future. The search for studies was conducted through electronic databases. Publications on coffee composition, coffee preparation and brewing methods, in vitro and in vivo experiments with the use of substances naturally present in coffee, observational studies, and meta-analyses were collected. In population studies, the greatest attention has been paid to the anticancer effect of caffeinated coffee and/or caffeine. In general, most studies and meta-analyses indicated that there was no clear correlation between coffee and breast cancer or ovarian cancer. Some subgroups of women may benefit from coffee consumption. This is the case for post-menopausal women with regard to the risk of breast cancer and obese women with regard to the risk of endometrial cancer. This paper identifies a number of issues for future research, related to a better understanding of the anti-cancer mechanisms of coffee compounds and further research that would focus on specific target groups, taking into account both the different methods of coffee preparation and lifestyle factors that may influence the results.
Acidri, R., Sawai, Y., Sugimoto, Y., Handa, T., Sasagawa, D., Masunaga, T., Yamamoto, S., Nishihara, E. (2020). Phytochemical profile and antioxidant capacity of coffee plant organs compared to green and roasted coffee beans. Antioxidants (Basel), 9(2), pii: E93.
Ali, A.T. (2014). Reproductive factors and the risk of endometrial cancer. International Journal of Gynecological Cancer, 24(3), 384-393.
Arthur, R., Kirsh, V.A., Rohan, T.E. (2018). Associations of coffee, tea and caffeine intake with risk of breast, endometrial and ovarian cancer among Canadian women. Cancer Epidemiology, 56, 75-82.
Allred, K.F., Yackley, K.M., Vanamala, J., Allred C.D. (2009). Trigonelline is a novel phytoestrogen in coffee beans. Journal of Nutrition, 139(10), 1833-1838.
Angeloni, S., Navarini, L., Sagratini, G., Torregiani, E., Vittori, S., Caprioli, G. (2018). Development of an extraction method for the quantification of lignans in espresso coffee by using HPLC-MS/MS triple quadrupole. Journal of Mass Spectrometry, 53(9), 842-848.
Aquino-Gálvez, A., González-Ávila, G., Delgado-Tello, J., Castillejos-López, M., Mendoza-Milla, C., Zúñiga, J., Checa, M., Maldonado-Martínez, H.A., Trinidad-López, A., Cisneros, J., Torres-Espíndola, L.M., Hernández-Jiménez, C., Sommer, B., Cabello-Gutiérrez, C., Gutiérrez-González, L.H. (2016). Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia. Oncology Reports, 35(1), 577-583.
Bakuradze, T., Lang, R., Hofmann, T., Eisenbrand, G., Schipp, D., Galan, J., Richling, E. (2015). Consumption of a dark roast coffee decreases the level of spontaneous DNA strand breaks: a randomized controlled trial. European Journal of Nutrition, 54(1), 149-156.
Barnung, R.B., Nøst, T.H., Ulven, S.M., Skeie, G., Olsen, K.S. (2018). Coffee consumption and whole-blood gene expression in the Norwegian women and cancer post-genome cohort. Nutrients, 10(8), 1047.
Beland, F.A., Mellick, P.W., Olson, G.R., Mendoza, M.C., Marques, M.M., Doerge, D.R. (2013). Carcinogenicity of acrylamide in B6C3F(1) mice and F344/N rats from a 2-year drinking water exposure. Food Chemistry and Toxicology, 51, 149-159.
Berretta, M., Micek, A., Lafranconi, A., Rossetti, S., Di Francia, R., De Paoli, P., Rossi, P., Facchini, G. (2018). Coffee consumption is not associated with ovarian cancer risk: a dose-response meta-analysis of prospective cohort studies. Oncotarget, 9(29), 20807-20815.
11. Bhoo-Pathy, N., Peeters, P.H., Uiterwaal, C.S., Bueno-de-Mesquita, H.B., Bulgiba, A.M., Bech, B.H., Overvad, K., Tjønneland, A., Olsen, A., Clavel-Chapelon, F., Fagherazzi, G., Perquier, F., Teucher, B., Kaaks, R., Schütze, M., Boeing, H., Lagiou, P., Orfanos, P., Trichopoulou, A., Agnoli, C., Mattiello, A., Palli, D., Tumino, R., Sacerdote, C., van Duijnhoven, F.J., Braaten, T., Lund, E., Skeie, G., Redondo, M.L., Buckland, G., Pérez, M.J., Chirlaque, M.D., Ardanaz, E., Amiano, P., Wirfält, E., Wallström, P., Johansson, I., Nilsson, L.M., Khaw, K.T., Wareham, N., Allen, N.E., Key, T.J., Rinaldi, S., Romieu, I., Gallo, V., Riboli, E., van Gils, C.H. (2015). Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study. Breast Cancer Research, 17(1), art. no. 15
Bhoo Pathy N., Peeters P., van Gils C., Beulens J.W., van der Graaf Y., Bueno-de-Mesquita B., Bulgiba, A., Uiterwaal, C.S. (2010). Coffee and tea intake and risk of breast cancer. Breast Cancer Research and Treatment, 121(2), 461-467.
Bissonauth, V., Shatenstein, B., Fafard, E., Maugard, C., Robidoux, A., Narod, S., Ghadirian, P. (2009). Risk of breast cancer among French-Canadian women, noncarriers of more frequent BRCA1/2 mutations and consumption of total energy, coffee, and alcohol. Breast Journal, 15(Suppl 1), S63-71.
Boettler, U., Sommerfeld, K., Volz, N., Pahlke, G., Teller, N., Somoza, V., Lang, R., Hofmann, T., Marko, D. (2011). Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. Journal of Nutritional Biochemistry, 22(5), 426-440.
Boggs, D.A., Palmer, J.R., Stampfer, M.J., Spiegelman, D., Adams-Campbell, L.L., Rosenberg, L. (2010). Tea and coffee intake in relation to risk of breast cancer in the Black Women's Health Study. Cancer Causes & Control, 21(11), 1941-1948.
Braem, M.G., Onland-Moret, N.C., Schouten, L.J., Tjønneland, A., Hansen, L., Dahm, C.C., Overvad, K., Lukanova, A., Dossus, L., Floegel, A., Boeing, H., Clavel-Chapelon, F., Chabbert-Buffet, N., Fagherazzi, G., Trichopoulou, A., Benetou, V., Goufa, I., Pala, V., Galasso, R., Mattiello, A., Sacerdote, C., Palli, D., Tumino, R., Gram, I.T., Lund, E., Gavrilyuk, O., Sánchez, M.J., Quirós, R., Gonzales, C.A., Dorronsoro, M., Castaño, J.M., Gurrea, A.B., Idahl, A., Ohlson, N., Lundin, E., Jirstrom, K,, Wirfalt, E., Allen, N.E., Tsilidis, K.K., Kaw, K.T., Bueno-de-Mesquita, H.B., Dik, V.K., Rinaldi, S., Fedirko, V., Norat, T., Riboli, E., Kaaks, R., Peeters, PH. (2012). Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis. American Journal of Clinical Nutrition, 95(5), 1172-1181.
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), 394-424.
Brown, S.B., Hankinson, S.E. (2015). Endogenous estrogens and the risk of breast, endometrial, and ovarian cancers. Steroids, 99(Pt A), 8-10.
Buchmann, S., Zahm, A., Kolling-Speer, I., Speer, K. (2011). Lipids in coffee brews - impact of grind size, water temperature, and coffee/water ratio on cafestol and the carboxylic acid-5-hydroxytryptamides. In: 23rd International Conference on Coffee Science, Bali, Indonesia, 3-8.10.2010, vol. 1. Curran Associates, Inc., Red Hook, NY, USA. pp. 84-92.
Cárdenas, C., Quesada, A.R., Medina, M.A. (2011). Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. PLoS ONE, 6(8), e23407.
Cárdenas, C., Quesada, A.R, Medina, M.Á. (2014). Insights on the antitumor effects of kahweol on human breast cancer: decreased survival and increased production of reactive oxygen species and cytotoxicity. Biochemical & Biophysical Research Communications, 447(3), 452-458.
Catalano, D., Trovato, G.M., Spadaro, D., Martines, G.F., Garufi, G., Tonzuso, A., Grasso, D., Sciacchitano, S.G. (2008). Insulin resistance in postmenopausal women: concurrent effects of hormone replacement therapy and coffee. Climacteric, 11(5), 373-382.
Centers for Disease Control and Prevention. Leading causes of death in females. CDC, 2013. Available online: (accessed on 6 December 2019).
DePaula, J., Farah, A. (2019). Caffeine consumption through coffee: content in the beverage, metabolism, health benefits and risks. Beverages, 2019, 5(2), art. no. 37.
Danaei, G., Vander Hoorn, S., Lopez, A.D., Murray, C.J., Ezzati, M. (2005). Comparative Risk Assessment collaborating group (Cancers). Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet, 366(9499), 1784-1793.
Diep, C.H., Daniel, A.R., Mauro, L.J., Knutson, T.P., Lange, C.A. (2015). Progesterone action in breast, uterine, and ovarian cancers. Journal of Molecular Endocrinology, 54(2), R31-R53.
Ding, M., Bhupathiraju, S.N., Chen, M., van Dam, R.M., Hu, F.B. (2014). Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review and a dose-response meta-analysis. Diabetes Care, 37(2), 569-586.
Doll, A., Abal, M., Rigau, M., Monge, M., Gonzalez, M., Demajo, S., Colás, E., Llauradó, M., Alazzouzi, H., Planagumá, J., Lohmann, M.A., Garcia, J., Castellvi, S., Ramon y Cajal, J., Gil-Moreno, A., Xercavins, J., Alameda, F., Reventós, J. (2008). Novel molecular profiles of endometrial cancer-new light through old windows. Journal of Steroid Biochemistry & Molecular Biology, 108(3-5), 221-229.
EFSA. (2011). Results on acrylamide levels in food from monitoring years 2007-2009 and exposure assessment. EFSA Journal, 9(4):2133.
EFSA Panel on Contaminants in the Food Chain (CONTAM). (2015). Scientific opinion on acrylamide in food. EFSA Journal, 13(6), 4104.
Endogenous Hormones and Breast Cancer Collaborative Group, Key, T.J., Appleby, P.N., Reeves, G.K., Travis, R.C., Alberg, A.J., Barricarte, A., Berrino, F., Krogh, V., Sieri, S., Brinton, L.A., Dorgan, J.F., Dossus, L., Dowsett, M., Eliassen, A.H., Fortner, R.T., Hankinson, S.E., Helzlsouer, K.J., Hoffman-Bolton, J., Comstock, G.W., Kaaks, R., Kahle, L.L., Muti, P., Overvad, K., Peeters, P.H., Riboli, E., Rinaldi, S., Rollison, D.E., Stanczyk, F.Z., Trichopoulos, D., Tworoger, S.S., Vineis, P. (2013). Sex hormones and risk of breast cancer in premenopausal women: a collaborative reanalysis of individual participant data from seven prospective studies. Lancet Oncology, 14(10), 1009-1019.
European Commission. The state of women's health in the European Community. Available online: (accessed on 6 December 2019).
Fagherazzi, G., Touillaud, M.S., Boutron-Ruault, M.C., Clavel-Chapelon, F., Romieu, I. (2011). No association between coffee, tea or caffeine consumption and breast cancer risk in a prospective cohort study. Public Health & Nutrition, 14(7), 1315-1320.
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D.M., Forman, D., Bray, F. (2015). Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer, 136(5), E359-E386.
Folkerd, E., Dowsett, M. (2013). Sex hormones and breast cancer risk and prognosis. Breast, 22(Suppl 2), S38-S43.
Ford, D., Easton, D.F., Stratton, M., Narod, S., Goldgar, D., Devilee, P., Bishop, D.T., Weber, B., Lenoir, G., Chang-Claude, J., Sobol, H., Teare, M.D., Struewing, J., Arason, A., Scherneck, S., Peto, J., Rebbeck, T.R., Tonin, P., Neuhausen, S., Barkardottir, R., Eyfjord, J., Lynch, H., Ponder, B.A., Gayther, S.A., Zelada-Hedman, M. and The Breast Cancer Linkage Consortium. (1998). Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. American Journal of Human Genetics, 62(3), 676-689.
Freisling, H., Moskal, A., Ferrari, P., Nicolas, G., Knaze, V., Clavel-Chapelon, F., Boutron-Ruault, M.C., Nailler, L., Teucher, B., Grote, V.A., Boeing, H., Clemens, M., Tjønneland, A., Olsen, A., Overvad, K., Quirós, J.R., Duell, E.J., Sánchez, M.J., Amiano, P., Chirlaque, M.D., Barricarte, A., Khaw, K.T., Wareham, N.J., Crowe, F.L., Gallo, V., Oikonomou, E., Naska, A., Trichopoulou, A., Palli, D., Agnoli, C., Tumino, R., Polidoro, S., Mattiello, A., Bueno-de-Mesquita, H.B., Ocké, M.C., Peeters, P.H., Wirfält, E., Ericson, U., Bergdahl, I.A., Johansson, I., Hjartåker, A., Engeset, D., Skeie, G., Riboli, E., Slimani, N. (2013). Dietary acrylamide intake of adults in the European Prospective Investigation into Cancer and Nutrition differs greatly according to geographical region. European Journal of Nutrition, 52(4), 1369-1380.
Friberg, E., Orsini, N., Mantzoros, C.S., Wolk, A. (2009). Coffee drinking and risk of endometrial cancer – a population-based cohort study. International Journal of Cancer, 125(10), 2413-2417.
Gapstur, S.M., Anderson, R.L., Campbell, P.T., Jacobs, E.J., Hartman, T.J., Hildebrand, J.S., Wang, Y., McCullough, M.L. (2017). Associations of coffee drinking and cancer mortality in the Cancer Prevention Study-II. Cancer Epidemiology, Biomarkers & Prevention, 26(10), 1477-1486.
Gavrilyuk, O, Braaten, T, Skeie, G, Weiderpass, E, Dumeaux, V, Lund, E. (2014). High coffee consumption and different brewing methods in relation to postmenopausal endometrial cancer risk in the Norwegian women and cancer study: a population-based prospective study. BMC Womens Health, 14(1), art. no. 48.
Gierach, G.L., Freedman, N.D., Andaya, A., Hollenbeck, A.R., Park, Y., Schatzkin, A., Brinton, L.A. (2012). Coffee intake and breast cancer risk in the NIH-AARP diet and health study cohort. International Journal of Cancer, 131(2), 452-460.
Giri, A., Sturgeon, S.R., Luisi, N., Bertone-Johnson, E., Balasubramanian, R., Reeves, K.W. (2011). Caffeinated coffee, decaffeinated coffee and endometrial cancer risk: a prospective cohort study among US postmenopausal women. Nutrients, 3(11), 937-950.
Gorska-Ponikowska, M., Kuban-Jankowska, A., Daca, A., Nussberger, S. (2017). 2-methoxyestradiol reverses the pro-carcinogenic effect of l-lactate in osteosarcoma 143B cells. Cancer Genomics & Proteomics, 14(6), 483-493.
Gosvig, C.F., Kjaer, S.K., Blaakær, J., Høgdall, E., Høgdall, C., Jensen, A. (2015). Coffee, tea, and caffeine consumption and risk of epithelial ovarian cancer and borderline ovarian tumors: results from a Danish case-control study. Acta Oncologica, 54(8), 1144-1151.
Gross, G., Jaccaud, E., Huggett, A.C. (1997). Analysis of the content of the diterpenes cafestol and kahweol in coffee brews. Food Chemistry & Toxicology, 35(6), 547-554.
Grosso, G., Micek, A., Godos, J., Sciacca, S., Pajak, A., Martínez-González, M.A., Giovannucci, E.L., Galvano, F. (2016). Coffee consumption and risk of all-cause, cardiovascular, and cancer mortality in smokers and non-smokers: a dose-response meta-analysis. European Journal of Epidemiology, 31(12), 1191-1205.
Grosso, G., Godos, J., Galvano, F., Giovannucci, E.L. (2017a). Coffee, caffeine, and health outcomes: an umbrella review. Annual Review of Nutrition, 37(1), 131-156.
Grosso, G., Stepaniak, U., Micek, A., Stefler, D., Bobak, M., Pajak, A. (2017b). Coffee consumption and mortality in three Eastern European countries: results from the HAPIEE (Health, Alcohol and Psychosocial factors In Eastern Europe) study. Public Health & Nutrition, 20(1), 82-91.
Gunter, M.J., Murphy, N., Cross, A.J., Dossus, L., Dartois, L., Fagherazzi, G., Kaaks, R., Kühn, T., Boeing, H., Aleksandrova, K., Tjønneland, A., Olsen, A., Overvad, K., Larsen, S.C., Redondo Cornejo, M.L., Agudo, A., Sánchez Pérez, M.J., Altzibar, J.M., Navarro, C., Ardanaz, E., Khaw, K.T., Butterworth, A., Bradbury, K.E., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Grioni, S., Vineis, P., Panico, S., Tumino, R., Bueno-de-Mesquita, B., Siersema, P., Leenders, M., Beulens, J.W.J., Uiterwaal, C.U., Wallström, P., Nilsson, L.M., Landberg, R., Weiderpass, E., Skeie, G., Braaten, T., Brennan, P., Licaj, I., Muller, D.C., Sinha, R., Wareham, N., Riboli, E. (2017). Coffee drinking and mortality in 10 European countries: A multinational cohort study. Annals of Internal Medicine, 167(4), 236-247.
Hashibe, M., Galeone, C., Buys, S.S., Gren, L., Boffetta, P., Zhang, Z.F., La Vecchia, C. (2015). Coffee, tea, caffeine intake, and the risk of cancer in the PLCO cohort. British Journal of Cancer, 113(5), 809-816.
He, Z., Ma, W.Y., Hashimoto, T., Bode, A.M., Yang, C.S., Dong, Z. (2003). Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways. Cancer Research, 63(15), 4396-4401.
Hernandez, A.V., Pasupuleti, V., Benites-Zapata, V.A., Thota, P., Deshpande, A., Perez-Lopez, F.R. (2015). Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis. European Journal of Cancer, 51(18), 2747-2758.
Hogervorst, J.G., Schouten, L.J., Konings, E.J., Goldbohm, R.A., van den Brandt, P.A. (2007). A prospective study of dietary acrylamide intake and the risk of endometrial, ovarian, and breast cancer. Cancer Epidemiology, Biomarkers & Prevention, 16(11), 2304-2313.
Huber, W.W., Parzefall, W. (2005). Modification of N-acetyltransferases and glutathione S-transferases by coffee components: possible relevance for cancer risk. Methods in Enzymology, 401, 307-341.
Huber, W.W., Scharf, G., Nagel, G., Prustomersky, S., Schulte-Hermann, R., Kaina, B. (2003). Coffee and its chemopreventive components kahweol and cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver - comparison with phase II xenobiotic metabolism. Mutation Research, 522(1-2), 57-68.
Ito, K., Nakazato, T., Miyakawa, Y., Yamato, K., Ikeda, Y., Kizaki, M. (2003). Caffeine induces G2/M arrest and apoptosis via a novel p53-dependent pathway in NB4 promyelocytic leukemia cells. Journal of Cell Physiology, 196(2), 276-283.
Je, Y, Giovannucci, E. (2012). Coffee consumption and risk of endometrial cancer: findings from a large up-to-date meta-analysis. International Journal of Cancer, 131(7), 1700-1710.
Je, Y., Hankinson, S.E., Tworoger, S.S., De Vivo, I., Giovannucci, E. (2011). A prospective cohort study of coffee consumption and risk of endometrial cancer over a 26-year follow-up. Cancer Epidemiology, Biomarkers & Prevention, 20(12), 2487-2495.
Jeon, J.S., Kim, H.T, Jeong, I.H., Hong, S.R., Oh, M.S., Yoon, M.H., Shim, J.H., Jeong, J.H., Abd El-Aty, A.M. (2019). Contents of chlorogenic acids and caffeine in various coffee-related products. Journal of Advanced Research,17, 85-94.
Jiang, W., Wu, Y., Jiang, X. (2013). Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies. Gynecological Oncology, 129(3), 620-629.
Korir, M.W., Wachira, F.N., Wanyoko, J.K., Ngure, R.M., Khalid, R. (2014). The fortification of tea with sweeteners and milk and its effect on in vitro antioxidant potential of tea product and glutathione levels in an animal model. Food Chemistry, 145, 145-153.
Kotemori, A., Ishihara, J., Zha, L., Liu, R., Sawada, N., Iwasaki, M., Sobue, T., Tsugane, S., JPHC Study Group. (2018). Dietary acrylamide intake and risk of breast cancer: The Japan Public Health Center-based Prospective Study. Cancer Science, 109(3), 843-853.
Kotsopoulos, J., Eliassen, A.H., Missmer, S.A., Hankinson, S.E., Tworoger, S.S. (2009). Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women. Cancer, 115(12), 2765-2774.
Kotsopoulos, J., Ghadirian, P., El-Sohemy, A., Lynch, H.T., Snyder, C., Daly, M., Domchek, S., Randall, S., Karlan, B., Zhang, P., Zhang, S, Sun P., Narod, S.A. (2007). The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers. Cancer Epidemiology, Biomarkers & Prevention, 16(5), 912-916.
Lafranconi, A., Micek, A., De Paoli, P., Bimonte, S., Rossi, P., Quagliariello, V., Berretta, M. (2018). Coffee intake decreases risk of postmenopausal breast cancer: a dose-response meta-analysis on prospective cohort studies. Nutrients, 10(2), art no. e112.
Lafranconi, A., Micek, A., Galvano, F., Rossetti, S., Del Pup, L., Berretta, M., Facchini, G. (2017). Coffee decreases the risk of endometrial cancer: a dose-response meta-analysis of prospective cohort studies. Nutrients, 9(11). art. no. e1223.
Lang, R., Yagar, E.F., Eggers, R., Hofmann, T. (2008). Quantitative investigation of trigonelline, nicotinic acid, and nicotinamide in foods, urine, and plasma by means of LC-MS/MS and stable isotope dilution analysis. Journal of Agricultural and Food Chemistry, 56(23), 11114-11121.
Larsson, S.C., Akesson, A., Wolk, A. (2009). Long-term dietary acrylamide intake and risk of epithelial ovarian cancer in a prospective cohort of Swedish women. Cancer Epidemiology, Biomarkers & Prevention, 18(3), 994-997.
Lee, P.M.Y, Chan, W.C., Kwok, C.C., Wu, C., Law, S.H., Tsang, K.H., Yu, W.C., Yeung, Y.C., Chang, L.D.J., Wong, C.K.M., Wang, F., Tse, L.A. (2019). Associations between coffee products and breast cancer risk: a case-control study in Hong Kong Chinese women. Scientific Reports, 2019, 9(1), art. no. 12684.
Leung, A.C., Cook, L.S., Swenerton, K., Gilks, B., Gallagher, R.P., Magliocco, A., Steed, H., Köbel, M., Nation, J., Brooks-Wilson, A., Le N.D. (2016). Tea, coffee, and caffeinated beverage consumption and risk of epithelial ovarian cancers. Cancer Epidemiology, 45, 119-125.
Li, J., Seibold, P., Chang-Claude, J., Flesch-Janys, D., Liu, J., Czene, K., Humphreys, K., Hall, P. (2011). Coffee consumption modifies risk of estrogen-receptor negative breast cancer. Breast Cancer Research, 13(3), R49.
Liu, Q.P., Wu, Y.F., Cheng, H.Y., Xia, T., Ding, H., Wang, H., Wang, Z.M., Xu, Y. (2016). Habitual coffee consumption and risk of cognitive decline/dementia: A systematic review and meta-analysis of prospective cohort studies. Nutrition, 32(6), 628-636.
Loftfield, E., Shiels, M.S., Graubard, B.I., Katki, H.A., Chaturvedi, A.K., Trabert, B., Pinto, L.A., Kemp, T.J., Shebl, F.M., Mayne, S.T., Wentzensen, N., Purdue, M.P., Hildesheim, A., Sinha, R., Freedman, N.D. (2015). Associations of coffee drinking with systemic immune and inflammatory markers. Cancer Epidemiology, Biomarkers & Prevention, 24(7), 1052-1060.
Ludwig, I.A., Mena, P., Calani, L., Cid, C., Del Rio, D., Lean, M.E., Crozier, A. (2014). Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking? Food & Function, 5(8), 1718-1726.
Lukic, M., Guha, N., Licaj, I., van den Brandt, P.A., Stayner, L.T., Tavani, A., Weiderpass, E. (2018). Coffee drinking and the risk of endometrial cancer: an updated meta-analysis of observational studies. Nutrition & Cancer, 70(4), 513-528.
Lukic, M., Licaj, I., Lund, E., Skeie, G., Weiderpass, E., Braaten, T. (2016). Coffee consumption and the risk of cancer in the Norwegian women and cancer (NOWAC) Study. European Journal of Epidemiology, 31(9), 905-916.
Madeira, M.H., Boia, R., Ambrósio, A.F., Santiago, A.R. (2017). Having a coffee break: the impact of caffeine consumption on microglia-mediated inflammation in neurodegenerative diseases. Mediators of Inflammation, 2017, art. no. 4761081.
Mazur, W.M., Wähälä, K., Rasku, S., Salakka, A., Hase, T., Adlercreutz, H. (1998). Lignan and isoflavonoid concentrations in tea and coffee. British Journal of Nutrition, 79(1), 37-45.
Mellbye, F.B., Jeppesen, PB., Hermansen, K., Gregersen, S. (2015). Cafestol, a bioactive substance in coffee, stimulates insulin secretion and increases glucose uptake in muscle cells: Studies in vitro. Journal of Natural Products, 78(10), 2447-2451.
Mensink, R.P., Lebbink, W.J., Lobbezoo, I.E., Weusten-Van der Wouw, M.P., Zock, P.L., Katan, M.B. (1995). Diterpene composition of oils from Arabica and Robusta coffee beans and their effects on serum lipids in man. Journal of Internal Medicine, 237(6), 543-550.
Merritt, M.A., Tzoulaki, I., Tworoger, S.S., De Vivo, I., Hankinson, S.E., Fernandes, J., Tsilidis, K.K., Weiderpass, E., Tjønneland, A., Petersen, K.E., Dahm, CC., Overvad, K., Dossus, L., Boutron-Ruault, M.C., Fagherazzi, G., Fortner, R.T., Kaaks, R., Aleksandrova, K., Boeing, H., Trichopoulou, A., Bamia, C., Trichopoulos, D., Palli, D., Grioni, S., Tumino, R., Sacerdote, C., Mattiello, A., Bueno-de-Mesquita, H.B., Onland-Moret, N.C., Peeters, P.H., Gram, I.T., Skeie, G., Quirós, J.R., Duell, E.J., Sánchez, M.J., Salmerón, D., Barricarte, A., Chamosa, S., Ericson, U., Sonestedt, E., Nilsson, L.M., Idahl, A., Khaw, K.T., Wareham, N., Travis, R.C., Rinaldi, S., Romieu, I., Patel, C.J., Riboli, E., Gunter, M.J. (2015). Investigation of dietary factors and endometrial cancer risk using a nutrient-wide association study approach in the EPIC and Nurses' Health Study (NHS) and NHSII. Cancer Epidemiology, Biomarkers & Prevention, 24(2), 466-471.
Michels, K.A., Brinton, L.A., Wentzensen, N., Pan, K., Chen, C., Anderson, G.L., Pfeiffer, R.M., Xu, X., Rohan, T.E., Trabert, B. (2019). Postmenopausal androgen metabolism and endometrial cancer risk in the Women's Health Initiative Observational Study. JNCI Cancer Spectrum, 3(3), art. no. pkz029.
Mojska, H., Gielecińska, I., Szponar, L., Ołtarzewski, M. (2010). Estimation of the dietary acrylamide exposure of the Polish population. Food and Chemical Toxicology, 48(8-9), 2090-2096.
Mojska, H., Gielecińska, I. (2013). Studies of acrylamide level in coffee and coffee substitutes: influence of raw material and manufacturing conditions. Roczniki Państwowego Zakładu Higieny, 64(3), 173-181.
Nagata, C., Kabuto, M., Shimizu, H. (1998). Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women. Nutrition & Cancer, 30(1), 21-24.
Nikitina, D., Chen, Z., Vallis, K., Poll, A., Ainsworth, P., Narod, S.A., Kotsopoulos, J. (2015). Relationship between caffeine and levels of DNA repair and oxidative stress in women with and without a BRCA1 mutation. Journal of Nutrigenetics & Nutrigenomics, 8(4-6), 174-184.
Nilsson, L.M., Johansson, I., Lenner, P., Lindahl, B., Van Guelpen, B. (2010). Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study. Cancer Causes Control, 21(10), 1533-1544.
Nkondjock, A., Ghadirian, P., Kotsopoulos, J., Lubinski, J., Lynch, H., Kim-Sing, C., Horsman, D., Rosen, B., Isaacs, C., Weber, B., Foulkes, W., Ainsworth, P., Tung, N., Eisen, A., Friedman, E., Eng, C., Sun, P., Narod, S.A. (2006). Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. International Journal of Cancer, 118(1), 103-107.
Obón-Santacana, M., Lujan-Barroso, L., Travis, R.C., Freisling, H., Ferrari, P., Severi, G., Baglietto, L., Boutron-Ruault, M.C., Fortner, R.T., Ose, J., Boeing, H., Menéndez, V., Sánchez-Cantalejo, E., Chamosa, S., Castaño, J.M., Ardanaz, E., Khaw, K.T., Wareham, N., Merritt, M.A., Gunter, M.J., Trichopoulou, A., Papatesta, E.M., Klinaki, E., Saieva, C., Tagliabue, G., Tumino, R., Sacerdote, C., Mattiello, A., Bueno-de-Mesquita, H.B., Peeters, P.H., Onland-Moret, N.C., Idahl, A., Lundin, E., Weiderpass, E., Vesper, H.W., Riboli, E., Duell, E.J. (2016). Acrylamide and glycidamide hemoglobin adducts and epithelial ovarian cancer: a nested case-control study in nonsmoking postmenopausal women from the EPIC cohort. Cancer Epidemiology, Biomarkers & Prevention, 25(1), 127-134.
Oh, J.K., Sandin, S., Ström, P., Löf, M., Adami, H.O., Weiderpass, E. (2015). Prospective study of breast cancer in relation to coffee, tea and caffeine in Sweden. International Journal of Cancer, 137(8), 1979-1989.
Ong, J.S., Hwang, L.D., Cuellar-Partida, G., Martin, N.G., Chenevix-Trench, G., Quinn, M.C.J., Cornelis, M.C., Gharahkhani, P., Webb, P.M., MacGregor, S. (2018). Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. International Journal of Epidemiology, 47(2), 450-459.
Park, S.Y., Freedman, N.D., Haiman, C.A., Le Marchand, L., Wilkens, L.R., Setiawan, V.W. (2018). Prospective study of coffee consumption and cancer incidence in non-white populations. Cancer Epidemiology, Biomarkers & Prevention, 27(8), 928-935.
Pelucchi, C., Bosetti, C., Galeone, C., La Vecchia, C. (2015). Dietary acrylamide and cancer risk: an updated meta-analysis. International Journal of Cancer, 136(12), 2912-2922.
Poole, R., Kennedy, O.J., Roderick, P., Fallowfield, J.A., Hayes, P.C., Parkes, J. (2017). Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ, 359, art. no. j5024.
Qi, H., Li, S. (2014). Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease. Geriatrics & Gerontology International, 14(2), 430-439.
Raglan, O., Kalliala, I., Markozannes, G., Cividini, S., Gunter, M.J., Nautiyal, J., Gabra, H., Paraskevaidis, E., Martin-Hirsch, P., Tsilidis, K.K., Kyrgiou, M. (2019). Risk factors for endometrial cancer: An umbrella review of the literature. International Journal of Cancer, 145(7), 1719-1730.
Rietjens, I.M.C.M., Louisse, J., Beekmann, K. (2017). The potential health effects of dietary phytoestrogens. British Journal Pharmacology, 174(11), 1263-1280.
Rodríguez-Artalejo, F., López-García, E. (2018). Coffee consumption and cardiovascular disease: a condensed review of epidemiological evidence and mechanisms. Journal of Agricultural and Food Chemistry, 66(21), 5257-5263.
Rosendahl, A.H., Perks, C.M., Zeng, L., Markkula, A., Simonsson, M., Rose, C., Ingvar, C., Holly, J.M., Jernström, H. (2015). Caffeine and caffeic acid inhibit growth and modify estrogen receptor and insulin-like growth factor I receptor levels in human breast cancer. Clinical Cancer Research, 21(8), 1877-1887.
Rossi, M., Tavani, A., Ciociola, V., Ferraroni, M., Parpinel, M., Serafini, M., Bellocco, R., Zucchetto, A., Montella, M., Serraino, D., Lagiou, P., La Vecchia, C. (2016). Dietary total antioxidant capacity in relation to endometrial cancer risk: a case-control study in Italy. Cancer Causes & Control, 27(3), 425-431.
Saiki, S., Sasazawa, Y., Imamichi, Y., Kawajiri, S., Fujimaki, T., Tanida, I., Kobayashi, H., Sato, F., Sato, S., Ishikawa, K., Imoto, M., Hattori, N. (2011). Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy, 7(2), 176-187.
Sapozhnikova, Y. (2014). Development of liquid chromatography-tandem mass spectrometry method for analysis of polyphenolic compounds in liquid samples of grape juice, green tea and coffee. Food Chemistry, 150, 87-93.
Samoggia, A., Riedel, B. (2019). Consumers' perceptions of coffee health benefits and motives for coffee consumption and purchasing. Nutrients, 11(3), art. no. e653.
Shafiei, F., Salari-Moghaddam, A., Milajerdi, A., Larijani, B., Esmaillzadeh, A. (2019). Coffee and caffeine intake and risk of ovarian cancer: a systematic review and meta-analysis. International Journal of Gynecology & Cancer, 29(3), 579-584.
Sirota, R., Gibson, D., Kohen, R. (2015). The role of the catecholic and the electrophilic moieties of caffeic acid in Nrf2/Keap1 pathway activation in ovarian carcinoma cell lines. Redox Biology, 4, 48-59.
Sisti, J.S., Hankinson, S.E., Caporaso, N.E., Gu, F., Tamimi, R.M., Rosner, B., Xu, X., Ziegler, R., Eliassen, A.H. (2015). Caffeine, coffee, and tea intake and urinary estrogens and estrogen metabolites in premenopausal women. Cancer Epidemiology, Biomarkers & Prevention, 24(8), 1174-1183.
Tai, J., Cheung, S., Chan, E., Hasman, D. (2010). Antiproliferation effect of commercially brewed coffees on human ovarian cancer cells in vitro. Nutrition & Cancer, 62(8), 1044-1057.
Teixeira, J., Gaspar, A., Garrido, E.M., Garrido, J., Borges, F. (2013). Hydroxycinnamic acid antioxidants: an electrochemical overview. BioMed Research International, 2013, art. no. 251754.
Tetens, I., Turrini, A., Tapanainen, H., Christensen, T., Lampe, J.W., Fagt, S., Håkansson, N., Lundquist, A., Hallund, J., Valsta, L.M. (2013). The Phytohealth WP1 working group. Dietary intake and main sources of plant lignans in five European countries. Food & Nutrition Research, 57(1), art. no. 19805.
Uccella, S., Mariani, A., Wang, A.H., Vierkant, R.A., Cliby, W.A., Robien, K., Anderson, K.E., Cerhan, J.R. (2013). Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer. British Journal of Cancer, 109(7), 1908-1913.
Vinholes, J., Silva, B.M., Silva, L.R. (2015). Hydroxycinnamic acids (HCAS): Structure, biological properties and health effects. In Leon V. Berhardt (Ed)., Advances in Medicine and Biology, Nova Science Publishers, Hauppauge (NY), USA. pp. 1-33.
Weiderpass, E., Sandin, S., Lof, M., Oh, J.K., Inoue, M., Shimazu, T., Tsugane, S., Adami, H.O. (2014). Endometrial cancer in relation to coffee, tea, and caffeine consumption: a prospective cohort study among middle-aged women in Sweden. Nutrition & Cancer, 66(7), 1132-1143.
Wierzejska, R. (2016). Coffee consumption and cardiovascular diseases – has the time come to change dietary advice? A mini review. Polish Journal of Food and Nutrition Sciences, 66(1), 5–10.
Wilson, K.M., Mucci, L.A., Cho, E., Hunter, D.J., Chen, W.Y., Willett, W.C. (2009). Dietary acrylamide intake and risk of premenopausal breast cancer. American Journal of Epidemiology, 169(8), 954-961.
Wilson, K.M., Mucci, L.A., Rosner, B.A., Willett, W.C. (2010). A prospective study on dietary acrylamide intake and the risk for breast, endometrial, and ovarian cancers. Cancer Epidemiology, Biomarkers & Prevention, 19(10), 2503-2515.
Witkowska, A.M., Waśkiewicz, A., Zujko, M.E., Szcześniewska, D., Stepaniak, U., Pająk, A., Drygas, W. (2018). Are total and individual dietary lignans related to cardiovascular disease and its risk factors in postmenopausal women? A nationwide study. Nutrients, 10(7), art. no. e865.
Witkowska, A.M., Zujko, M.E., Waśkiewicz, A., Terlikowska, K.M., Piotrowski, W. (2015). Comparison of various databases for estimation of dietary polyphenol intake in the population of Polish adults. Nutrients, 7(11), 9299-9308.
World Health Organization. International Agency for Research on Cancer. (2018). IARC monographs on the evaluation of carcinogenic risks to humans. Some industrial chemicals. IARC, Lyon, France, pp. 247-289.
Zamora-Ros, R., Knaze, V., Luján-Barroso, L., Kuhnle, G.G., Mulligan, A.A., Touillaud, M., Slimani, N., Romieu, I., Powell, N., Tumino, R., Peeters, P.H., de Magistris, M.S., Ricceri, F., Sonestedt, E., Drake, I., Hjartåker, A., Skie, G., Mouw, T., Wark, P.A., Romaguera, D., Bueno-de-Mesquita, H.B., Ros, M., Molina, E., Sieri, S., Quirós, J.R., Huerta, J.M., Tjønneland, A., Halkjær, J., Masala, G., Teucher, B., Kaas, R., Travis, R.C., Dilis, V., Benetou, V., Trichopoulou, A., Amiano, P., Ardanaz, E., Boeing, H., Förster, J., Clavel-Chapelon, F., Fagherazzi, G., Perquier, F., Johansson, G., Johansson, I., Cassidy, A., Overvad, K., González, C.A. (2012). Dietary intakes and food sources of phytoestrogens in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24-hour dietary recall cohort. European Journal of Clinical Nutrition, 66(8), 932-941.
Zhang, C., Linforth, R., Fisk, I.D. (2012). Cafestol extraction yield from different coffee brew mechanisms. Food Research International, 49(1), 27-31.
Zhou, Q., Luo, M.L., Li, H., Li, M., Zhou, J.G. (2015). Coffee consumption and risk of endometrial cancer: a dose-response meta-analysis of prospective cohort studies. Scientific Reports, 5, art. no. 13410.
Zhu, B.T., Wang, P., Nagai, M., Wen, Y., Bai, H.W. (2009). Inhibition of human catechol-O-methyltransferase (COMT)-mediated O-methylation of catechol estrogens by major polyphenolic components present in coffee. Journal of Steroid Biochemistry and Molecular Biology, 113(1-2), 65-74.
Zhu, Y., Kawaguchi, K., Kiyama, R. (2017). Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors. PLoS ONE, 12(2), art. no. e0171390.
Ziegler, R.G., Fuhrman, B.J., Moore, S.C., Matthews, C.E. (2015). Epidemiologic studies of estrogen metabolism and breast cancer. Steroids, 99, 67-75.
Yaghjyan, L., Rich, S., Mao, L., Mai, V., Egan, KM. (2018). Interactions of coffee consumption and postmenopausal hormone use in relation to breast cancer risk in UK Biobank. Cancer Causes & Control, 29(6), 519-525.
Yang, T.O., Crowe, F., Cairns, B.J., Reves, G.K., Beral, V. (2015). Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis. American Journal of Clinical Nutrition, 101(3), 570-578.
The Effect of Brewing Process Parameters on Antioxidant Activity and Caffeine Content in Infusions of Roasted and Unroasted Arabica Coffee Beans Originated from Different Countries
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Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota
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