EFFECT OF NON-ENZYMATIC GLYCATION ON BIOLOGICAL PROPERTIES OF MORPHICEPTIN.
 
More details
Hide details
 
Pol. J. Food Nutr. Sci. 2000;50(1):39–42
KEYWORDS
ABSTRACT
In the course of food proteins digestion, mid-molecular weight opioid peptides are generated. Their amine groups might undergo non-enzymatic glycation with glucose which is promoted by pH and temperature. The glycation conditions of morphiceptin (pH 7.8 and temp. 37oC) used in this experiment proved that non-enzymatic glycation of the peptides could take place in the digestive tract. The results obtained herein suggest that glycation decreases the contraction amplitude of isolated rabbit duodenum by 14.1% and changes the immunogenicity of morphiceptin (Tyr-Pro-Phe-Pro-NH2), probably due to a new epitope produced.
ISSN:1230-0322