NON-ENZYMATIC GLYCOSYLATION OF GUANOSINE-5’-TRIPHOSPHATE- A SHORT REPORT
 
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Pol. J. Food Nutr. Sci. 2006;56(1):67–70
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ABSTRACT
The influence of the non-enzymatic glycosylation (glycation) of guanosine-5’-triphosphate (GTP) by glucose on its physicochemical properties was investigated. The progress of glycation was monitored by the ionic-exchange chromatography. The results of analysis of the glycated mixture enabled identifying its three components: free GTP, glycated GTP and GTP-glycated complex. These results were also confirmed by spectral analysis and thin layer chromatography. Moreover, it was suggested that the glycation of nucleic acids could change their nutritive value, e.g. immunogenic and allergic potential.
ISSN:1230-0322