Authors provided a retrospective analysis of IgE-dependent food allergy clinical symptoms in 339 children aged from 0 to 36 months of life. Among them 246 patients (72.6%) had food allergy, 93 patients (27.4%) had inhalatory and food allergy. The analysis was based on medical documentation. The results demonstrated that 244 children (71.9%) manifested symptoms concerning the respiratory tract, while 168 (49.5%) had skin lesions. They showed that 71.9% of children had respiratory tract symptoms. Simultaneous manifestation of the allergic process in at least two systems was confirmed in 153 children (45.2%). It was observed that clinical manifestation of allergy changed with the age of the examined: the percentage of children manifesting symptoms related to the respiratory tract showed an upward tendency with age and a downward tendency in the case of digestive tract symptoms. The results of the study revealed also that cow’s milk protein is an allergen most often responsible for the occurrence of food allergy symptoms in infants and small children.