ANTIMICROBIAL ACTIVITY AND CYTOTOXICITY OF PICOLINIC ACID AND SELECTED PICOLINATES AS NEW POTENTIAL FOOD PRESERVATIVES

In this study antimicrobial activity of picolinic acid (PA), sodium picolinate (PS), potassium picolinate (PP), benzoic acid (BA), sodium benzoate (BS) and potassium benzoate (BP) against Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis and Candida albicans were measured using microbroth dilution method. Cytotoxicity assay of PS and BS was estimated in the human skin fibroblasts using Thiazolyl Blue Tetrazolium Bromide (MTT) test and DNA-binding assay. PA and PS showed antimicrobial activity at concentrations 0.02 to 0.78 mg/mL at pH=5.0 and 0.19 to 3.13 mg/mL at pH=7.0. Minimal inhibitory concentration (MIC) of BA on tested microorganisms was found at 0.13-0.50 mg/mL (pH=5.0) and about 1 mg/mL at pH=7.0. PA and PS showed strong antimicrobial activity, without significant influence on DNA synthesis and survival of human fibroblasts. The data suggest that PA and PS may represent new potential food preservatives.

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eISSN:	2083-6007
ISSN:	1230-0322

W latach 2022-2024 kwartalnik naukowy Polish Journal of Food and Nutrition Sciences realizuje projekt nr RCN/SP/0520/2021/1 finansowany ze środków budżetu państwa – Ministerstwo Edukacji i Nauki w ramach programu „Rozwój czasopism naukowych”. Dofinansowanie wynosi 120 000 zł. W ramach projektu podejmowane są działania zmierzające do podniesienia poziomu praktyk wydawniczych i edytorskich, zwiększenia wpływu czasopism na rozwój nauki oraz utrzymania się czasopism w międzynarodowym obiegu naukowym.

In the years 2022-2024, the scientific quarterly Polish Journal of Food and Nutrition Sciences accomplishes a project no. RCN/SP/0520/2021/1 financed from the state budged – Ministry of Education and Science Republic of Poland in the framework of a program “Development of scientific journals”. The financing amounts to 120,000 PLN. The program aims at improving the level of publishing and editing practices, increasing the impact of scientific journals on science development, and extending the international range of scientific journals.