IMPACT OF CHOLESTEROL, VITAMIN E SUPPLEMENTATION AND DIETARY FATTY ACIDS ON TESTIS FUNCTION IN HIGH-FAT DIET FED RATS
 
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Pol. J. Food Nutr. Sci. 2006;56(Special issue 2s):21–24
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ABSTRACT:
The aim of the study was to determine whether consumption of diets containing different fat (rapeseed oil or lard-rich), supplemented with a high level of cholesterol (3% w/w) and/or vitamin E (500 mg/kg of diet) for 6 weeks influenced 17beta-hydroxysteroid dehydrogenase (17β-HSD) type 3 activity (measured in vitro), testosterone (Tt) content in testes and plasma testosterone (Tp) concentration (measured by ELISA and RIA, respectively) in male rats. 17β-HSD activity was shown to depend on dietary fat type. Supplementation of vitamin E influenced Tt value, whereas none of the investigated dietary factors had effects on Tp. Significant differences between the investigated factors were observed only for groups fed rapeseed oil-rich diets with marked increases of Tt and Tp in rats fed vitamin E-rich diet.