EFFECT OF HIGH-FAT DIETS WITH DIFFERENT FATTY ACID COMPOSITION ON HEPATIC 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVITY IN RATS

Recent studies suggest a key role for tissue aberrant expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and for tissue glucocorticoid excess in dysregulation of metabolism observed in diabetes and other metabolic disorders linked to central obesity. In an experiment carried out in 50 adult Wistar rats fed on diets containing sunflower oil, rapeseed oil, lard or cod liver oil at two levels (20 and 40% w/w), we were the first to show a beneficial inhibitory effect of all fats but one (sunflower oil) on hepatic 11β-HSD1 activity, given the moderately high consumption of fat (i.e. 20%).

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eISSN:	2083-6007
ISSN:	1230-0322

W latach 2022-2024 kwartalnik naukowy Polish Journal of Food and Nutrition Sciences realizuje projekt nr RCN/SP/0520/2021/1 finansowany ze środków budżetu państwa – Ministerstwo Edukacji i Nauki w ramach programu „Rozwój czasopism naukowych”. Dofinansowanie wynosi 120 000 zł. W ramach projektu podejmowane są działania zmierzające do podniesienia poziomu praktyk wydawniczych i edytorskich, zwiększenia wpływu czasopism na rozwój nauki oraz utrzymania się czasopism w międzynarodowym obiegu naukowym.

In the years 2022-2024, the scientific quarterly Polish Journal of Food and Nutrition Sciences accomplishes a project no. RCN/SP/0520/2021/1 financed from the state budged – Ministry of Education and Science Republic of Poland in the framework of a program “Development of scientific journals”. The financing amounts to 120,000 PLN. The program aims at improving the level of publishing and editing practices, increasing the impact of scientific journals on science development, and extending the international range of scientific journals.