EFFECT OF VITAMIN C ON SERUM PROTEIN PROFILE IN MICE AFTER ALUMINUM SULPHATE INTOXICATION
 
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Pol. J. Food Nutr. Sci. 2006;56(3):339–348
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ABSTRACT
We tested the effect of aluminum sulphate on serum protein profile, liver enzyme activities, bilirubin levels, total protein content and the efficiency of vitamin C to reduce the adverse effect of aluminum sulphate. Mice were treated orally for 1, 2 and 3 weeks with three doses of aluminum sulphate 387.5, 775 and 1550 mg/kg b.wt. representing 1/16, 1/8 and 1/4 LD50, respectively. Significant reduction in serum total protein content and protein fraction concentrations is noticed except serum albumin which recorded a significant increase in a dose-dependent relationship of aluminum sulphate through follow up of time. Liver function enzyme activities and bilirubin levels recorded significantly elevated levels with 1/4, 1/8 and 1/16 LD50 of aluminum sulphate at 1st, 2nd and 3rd weeks of treatment. Concurrent administration of vitamin C at a dose of 20 mg/kg b.wt. to healthy mice produced a significant increase in serum total protein content and protein fraction concentrations. No effect of vitamin C on bilirubin levels and liver function enzyme activities in healthy animals was observed. On the other hand, vitamin C ameliorated serum total protein content and protein fraction concentrations, bilirubin levels and liver function enzyme activities in mice when administrated with 1/4 LD50 of aluminum sulphate. Concerning the effect of different doses of aluminum sulphate within weeks, ANOVA test revealed significant variation among each group except normal control group which recorded insignificant change after 1st, 2nd, and 3rd week. In vitamin C-administrated healthy mice, only albumin concentration and bilirubin levels recorded a non significant variations within different weeks.
ISSN:1230-0322