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ORIGINAL ARTICLE
Exploring the Interactions Between Caffeic Acid and Human Serum Albumin Using Spectroscopic and Molecular Docking Techniques
1
Kidney Research Center, Tabriz University of Medical Sciences, Tabriz 5166-15731, Iran
2
Department of Biology, Faculty of Fundamental Sciences, University College of Nabi Akram (UCNA), Tabriz, Iran
3
Department of Food Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
4
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5
Department of Food Science and Technology, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
6
Centro Tecnológico de la Carne de Galicia, Parque Tecnológico de Galicia, 32900 San Cibrao das Viñas, Spain
7
Área de Tecnología de los Alimentos, Facultad de Ciencias de Ourense, Universidad de Vigo, 32004 Ourense, Spain
8
Department of Chemical and Physical Properties of Food, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-486 Olsztyn, Poland
Submission date: 2020-12-10
Final revision date: 2021-02-08
Acceptance date: 2021-02-10
Online publication date: 2021-02-24
Publication date: 2021-02-24
Corresponding author
Ryszard Amarowicz
Department of Chemical and Physical Properties of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Poland
Department of Chemical and Physical Properties of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Poland
Pol. J. Food Nutr. Sci. 2021;71(1):69-77
KEYWORDS
TOPICS
ABSTRACT
Ultraviolet-visible (UV–Vis) and fluorescence spectroscopy along with molecular docking were used to explore the interaction between human serum albumin (HSA) and caffeic acid (CA). CA is one of the major representatives of hydroxycinnamic acids in plants and is commonly present in plant-based foods. The mechanism by which CA quenched HSA fluorescence was determined to be static, and the values obtained for thermodynamic parameters indicated that the CA and HSA interaction was spontaneous. Hydrogen bonds and van der Waals forces were the main driving forces stabilizing the complex. The binding constant was in the order of 104/M and the number of binding sites for CA on HSA was calculated to be close to one. The results of fluorescence and UV–Vis spectroscopy showed that CA induced conformational changes in HSA structure. The distance of CA and the tryptophan residue of HSA, was determined to be ~2 nm by using Forster resonance energy transfer theory. The mode of binding and the binding site of CA on albumin were examined by performing molecular docking calculations. CA interacted with albumin in subdomain IA, and non–covalent interactions stabilized the complex. CA showed a high affinity for albumin, and thus this phenolic compound would be distributed in the body upon interacting with HSA.
ABBREVIATIONS
CA – caffeic acid; FRET – Forster resonance energy transfer; H–bonds – hydrogen bonds; HCAs – hydroxycinnamic acids; HAS – human serum albumin; IFE – internal filter effect; SV – Stern–Volmer; UV–Vis – ultraviolet-visible; and vdW – van der Waals.
REFERENCES (45)
1.
Adzet, T., Camarasa, J., Escubedo, E., Merlos, M. (1988). In vitro study of caffeic acid - bovine serum albumin interaction. European Journal of Drug Metabolism and Pharmacokinetics, 13(1), 11-14. https://doi.org/10.1007/BF0318....
2.
Belatik, A., Hotchandani, S., Bariyanga, J., Tajmir-Riahi, H. (2012). Binding sites of retinol and retinoic acid with serum albumins. European Journal of Medicinal Chemistry, 48, 114-123. https://doi.org/10.1016/j.ejme....
3.
Bhat, S., Azmi, A., Hadi, S. (2007). Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: Involvement of endogenous copper and a putative mechanism for anticancer properties. Toxicology and Applied Pharmacology, 218(3), 249-255. https://doi.org/10.1016/j.taap....
4.
Bourassa, P., Hasni, I., Tajmir-Riahi, H. (2011). Folic acid complexes with human and bovine serum albumins. Food Chemistry, 129(3), 1148-1155. https://doi.org/10.1016/j.food....
5.
Chen, G.-Z., Huang, X.-Z., Xu, J.-G., Zheng, Z., Wang, Z. (1990). The Methods of Fluorescence Analysis. 2nd edition, Science Press, Beijing, pp.112-117.
6.
Chen, J.H., Ho, C.-T. (1997). Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds. Journal of Agricultural and Food Chemistry, 45(7), 2374-2378. https://doi.org/10.1021/jf9700....
7.
Chung, M., Walker, P., Hogstrand, C. (2006). Dietary phenolic antioxidants, caffeic acid and Trolox, protect rainbow trout gill cells from nitric oxide-induced apoptosis. Aquatic Toxicology, 80(4), 321-328. https://doi.org/10.1016/j.aqua....
8.
Cui, F.-L., Fan, J., Li, J.-P., Hu, Z.-D. (2004). Interactions between 1-benzoyl-4-p-chlorophenyl thiosemicarbazide and serum albumin: investigation by fluorescence spectroscopy. Bioorganic & Medicinal Chemistry, 12(1), 151-157. https://doi.org/10.1016/j.bmc.....
9.
Dan, Q., Xiong, W., Liang, H., Wu, D., Zhan, F., Chen, Y., Ding, Li, B. (2019). Characteristic of interaction mechanism between β-lactoglobulin and nobiletin: A multi-spectroscopic, thermodynamics methods and docking study. Food Research International, 120, 255-263. https://doi.org/10.1016/j.food....
10.
Eftink, M.R. (1991). Fluorescence quenching reactions: Probing biological macromolecular structures. In T.G. Dewey (Ed.). Biophysical and Biochemical Aspects of Fluorescence Spectroscopy. 1st edition, Springer Science + Business Media LCC, New York, USA, chapter 1, pp. 1-42. https://doi.org/10.1007/978-1-...
11.
El-Seedi, H.R., El-Said, A.M.A. Khalifa, S.A.M., Göransson, U., Bohlin, L., Borg-Karlson, A.-K., Verpoorte, R. (2012). Biosynthesis, natural sources, dietary intake, pharmacokinetic properties, and biological activities of hydroxycinnamic acids. Journal of Agricultural and Food Chemistry, 60(44), 10877-10895. https://doi.org/10.1021/jf3018....
12.
Jahanban-Esfahlan, A., Dastmalchi, S., Davaran, S. (2016). A simple improved desolvation method for the rapid preparation of albumin nanoparticles. International Journal of Biomolecular Macromolecules, 91, 703-709. https://doi.org/10.1016/j.ijbi....
13.
Jahanban-Esfahlan, A., Davaran, S., Moosavi-Movahedi, A.A., Dastmalchi, S. (2017). Investigating the interaction of juglone (5-hydroxy-1,4-naphthoquinone) with serum albumins using spectroscopic and in silico methods. Journal of the Iranian Chemical Society, 14, 1527-1540. https://doi.org/10.1007/s13738....
14.
Jahanban-Esfahlan, A., Ostadrahimi, A., Jahanban-Esfahlan, R., Roufegarinejad, L., Tabibiazar, M., Amarowicz, R. (2019). Recent developments in the detection of bovine serum albumin. International Journal of Biomolecular Macromolecules,138, 602-617. https://doi.org/10.1016/j.ijbi....
15.
Jahanban-Esfahlan, A., Panahi-Azar, V., Sajedi, S. (2015). Spectroscopic and molecular docking studies on the interaction between N-acetyl cysteine and bovine serum albumin. Biopolymers, 103, 638-645. https://doi.org/10.1002/bip.22....
16.
Jahanban-Esfahlan, A., Roufegarinejad, L., Jahanban-Esfahlan, R., Tabibiazar, M., Amarowicz, R. (2020). Latest developments in the detection and separation of bovine serum albumin using molecularly imprinted polymers. Talanta, 207, art. no. 120317. https://doi.org/10.1016/j.tala....
17.
Lakowicz, J.R. (2006). Principles of Fluorescence Spectroscopy. 3rd edition, Springer Science + Business Media, New York, USA, chapter 13, pp. 443-452. https://doi.org/10.1007/978-0-....
18.
Lakowicz, J.R., Weber, G. (1973). Quenching of fluorescence by oxygen. Probe for structural fluctuations in macromolecules. Biochemistry, 12(21), 4161-4170. https://doi.org/10.1021/bi0074....
19.
Lehrer, S. (1971). Solute perturbation of protein fluorescence. Quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. Biochemistry, 10(17), 3254-3263. https://doi.org/10.1021/bi0079....
20.
Li, S., Huang, K., Zhong, M., Guo, J., Wang, W.-Z., Zhu, R. (2010). Comparative studies on the interaction of caffeic acid, chlorogenic acid and ferulic acid with bovine serum albumin. Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 77(3), 680-686. https://doi.org/10.1016/j.saa.....
21.
Min, J., Meng-Xia, X., Dong, Z., Yuan, L., Xiao-Yu, L., Xing, C. (2004). Spectroscopic studies on the interaction of cinnamic acid and its hydroxyl derivatives with human serum albumin. Journal of Molecular Structures, 692(1-3), 71-80. https://doi.org/10.1016/j.mols....
22.
Mrkalić, E., Jelićb, R., Stojanović, S., Sovrlić, M. (2021). Interaction between olanzapine and human serum albumin and effect of metal ions, caffeine and flavonoids on the binding: A spectroscopic study. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 249, art. no. 119295. https://doi.org/10.1016/j.saa.....
23.
Nair, M.S. (2018). Spectroscopic studies on the interaction of serum albumins with plant derived natural molecules. Applied Spectroscopy Reviews, 53(8), 636-666. https://doi.org/10.1080/057049....
24.
Olthof, M.R., Hollman, P. C.-H., Katan, M.B. (2001). Chlorogenic acid and caffeic acid are absorbed in humans. The Journal of Nutrition, 131(1), 66-71. https://doi.org/10.1093/jn/131....
25.
Pirjo, M., Hellström, J., Törrönen, R. (2006). Phenolic acids in berries, fruits, and beverages. Journal of Agricultural and Food Chemistry, 53(19), 7193-7199. https://doi.org/10.1021/jf0615....
26.
Precupas, A., Sandu, R., Cantemir, A.R., Anghel, D.-F., Popa, V.T. (2017). Interaction of caffeic acid with bovine serum albumin is complex: Calorimetric, spectroscopic and molecular docking evidence. New Journal of Chemistry, 41, 15003-15015. https://doi.org/10.1039/C7NJ03....
27.
Rashmi, H.B., Negi, P.S. (2020). Phenolic acids from vegetables: A review on processing stability and health benefits. Food Research International, 136, art. no. 109298. https://doi.org/10.1016/j.food....
28.
Razzak M.A., Lee, J.-E., Choi, S.S. (2019). Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin. Food Hydrocolloids, 91, 290-300. https://doi.org/10.1016/j.food....
29.
Ross, P.D., Subramanian, S. (1981). Thermodynamics of protein association reactions: forces contributing to stability. Biochemistry, 20(11), 3096-3102. https://doi.org/10.1021/bi0051....
30.
Roufegarinejad, L., Amarowicz, R., Jahanban-Esfahlan, A. (2019). Characterizing the interaction between pyrogallol and human serum albumin by spectroscopic and molecular docking methods. Journal of Biomolecular Structure and Dynamics, 37(11), 2766-2775. https://doi.org/10.1080/073911....
31.
Samari, F., Shamsipur, M., Hemmateenejad, B., Khayamian, T., Gharaghani, S. (2012). Investigation of the interaction between amodiaquine and human serum albumin by fluorescence spectroscopy and molecular modeling. European Journal of Medicinal Chemistry, 54, 255-263. https://doi.org/10.1016/j.ejme....
32.
Sinisi, V., Forzato, C., Cefarin, N., Navarini, L., Berti, F. (2015). Interaction of chlorogenic acids and quinides from coffee with human serum albumin. Food Chemistry, 168, 332-340. https://doi.org/10.1016/j.food....
33.
Skrt, M., Benedik, E., Podlipnik, C., Ulrih, N.P. (2012). Interactions of different polyphenols with bovine serum albumin using fluorescence quenching and molecular docking. Food Chemistry, 135, 2418–2424. https://doi.org/10.1016/j.food....
34.
Sova, M., Saso, L. (2020). Natural sources, pharmacokinetics, biological activities and health benefits of hydroxycinnamic acids and their metabolites. Nutrients, 12(8), art. no. 2190. https://doi.org/10.3390/nu1208....
35.
Sułkowska, A. (2002). Interaction of drugs with bovine and human serum albumin. Journal of Molecular Structure, 614(1-3), 227-232. https://doi.org/10.1016/S0022-...
36.
Suryaprakash, P., Kumar, R.P., Prakash, V. (2000). Thermodynamics of interaction of caffeic acid and quinic acid with multisubunit proteins. International Journal of Biological Macromolecules, 27(3), 219-228. https://doi.org/10.1016/S0141-....
37.
Sun, Q., Yang, H., Tang, P., Liu, J., Wang, W., Li, H. (2018). Interactions of cinnamaldehyde and its metabolite cinnamic acid with human serum albumin and interference of other food additives. Food Chemistry, 243, 74-81. https://doi.org/10.1016/j.food....
38.
Sudhamalla, B., Gokara, M., Ahalawat, N., Amooru, D.G., Subramanyam, R. (2010). Molecular dynamics simulation and binding studies of β-sitosterol with human serum albumin and its biological relevance. Journal of Physical Chemistry, 114(27), 9054-9062. https://doi.org/10.1021/jp1027....
39.
Tomašević, M., Lisjak, K., Vanzo, A., Ganić, K.K. (2019). Changes in the composition of aroma and phenolic compounds induced by different enological practices of Croatian white wine. Polish Journal of Food and Nutrition Sciences, 69(4), 343-358. https://doi.org/10.31883/pjfns....
40.
Ulrich, K.-H. (1981). Molecular aspects of ligand binding to serum albumin. Pharmacological Reviews, 33(1), 17-53.
41.
Ulrich, K.-H. (1990). Structure and ligand binding properties of human serum albumin. Danish Medical Bulletin, 37(1), 57-84.
42.
Wang, N., Ye, L., Yan, F., Xu, R. (2008). Spectroscopic studies on the interaction of azelnidipine with bovine serum albumin. International Journal of Pharmaceutics, 351(1-2), 55-60. https://doi.org/10.1016/j.ijph....
43.
Worldwide Protein Data Bank (wwPDB). Available online: [https://www.rcsb.org/structure...] (accessed on 10 April 2020).
44.
Zhang, Y., Yue, Y., Li, J., Chen, X. (2008). Studies on the interaction of caffeic acid with human serum albumin in membrane mimetic environments. Journal of Photochemistry and Photobiology B: Biology, 90(3), 141-151. https://doi.org/10.1016/j.jpho....
45.
Zou, Y.-C., Wu, C.-L., Ma, C.-F., He, S., Brennan, C.S., Yuan, Y. (2019). Interactions of grape seed procyanidins with soy protein isolate: Contributing antioxidant and stability properties. LWT – Food Science and Technology, 115, art. no. 108465. https://doi.org/10.1016/j.lwt.....
CITATIONS (44):
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17.
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Jing Kong, Mingyuan Li, Yutong Li, Min Liu, Qian Zhang, Jie Liu, HongZhuan Xuan
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Jing Kong, Mingyuan Li, Yutong Li, Min Liu, Qian Zhang, Jie Liu, HongZhuan Xuan
Journal of Molecular Liquids
33.
Investigating sulfonamides - Human serum albumin interactions: A comprehensive approach using multi-spectroscopy, DFT calculations, and molecular docking
Mingguo Peng, Yicui Wang, Chunge Wu, Xuewen Cai, Yao Wu, Erdeng Du, Lu Zheng, Jiajun Fu
Biochemical and Biophysical Research Communications
Mingguo Peng, Yicui Wang, Chunge Wu, Xuewen Cai, Yao Wu, Erdeng Du, Lu Zheng, Jiajun Fu
Biochemical and Biophysical Research Communications
34.
Assessment of the Binding of Pseudallecin A to Human Serum Albumin with Multi‐Spectroscopic Analysis, Molecular Docking and Molecular Dynamic Simulation
Ziyang Li, Ruolan Chen, Chan Qin, Peijun Lu, Jiaru Lin, Wenxu Zheng, Yahong Xiong, Chunyuan Li
Chemistry & Biodiversity
Ziyang Li, Ruolan Chen, Chan Qin, Peijun Lu, Jiaru Lin, Wenxu Zheng, Yahong Xiong, Chunyuan Li
Chemistry & Biodiversity
35.
Thermodynamic and structural investigation of the interaction of quaternized 2,3‐octakis‐[(2‐mercaptopyridine)phthalocyaninato] copper (II) sulfate (CuPc) with parallel and hybrid type G‐quadruplex
Gamze Şahin, Esra Bağda, Temiz Göktuğ, Efkan Bağda, Ebubekir Ayhan, Mahmut Durmuş
Journal of Molecular Recognition
Gamze Şahin, Esra Bağda, Temiz Göktuğ, Efkan Bağda, Ebubekir Ayhan, Mahmut Durmuş
Journal of Molecular Recognition
36.
Spectroscopic and molecular docking investigation on the interaction of a water-soluble Cu(II) complex containing diethanolamine and dipicolinic acid ligands with human serum albumin
Nahid Shahabadi, Azadeh Marzbani, Saba Hadidi, Zahra Mardani
Journal of Biomolecular Structure and Dynamics
Nahid Shahabadi, Azadeh Marzbani, Saba Hadidi, Zahra Mardani
Journal of Biomolecular Structure and Dynamics
37.
Investigating the binding of caffeic acid to human hemoglobin using multispectroscopic and molecular docking approaches
Monika Sharma, Md. Hashmi, Riaz Mahmood
Journal of Molecular Structure
Monika Sharma, Md. Hashmi, Riaz Mahmood
Journal of Molecular Structure
38.
Complexation of bovine lactoferrin with selected phenolic acids via non-covalent interactions: binding mechanism and altered functionality
Cuina Wang, Yingcong Lu, Boxue Xia, Xiang Li, Xin Huang, Chao Dong
Journal of Dairy Science
Cuina Wang, Yingcong Lu, Boxue Xia, Xiang Li, Xin Huang, Chao Dong
Journal of Dairy Science
39.
Analysis on the interaction of coumarin isomers with human serum albumin in the presence of cisplatin
Hongtian Yang, Liang Xu, Yuanhao Liang, Yuan Chen, Yancheng Li, Xiaoying Fan, Yufeng Liu
Journal of Molecular Structure
Hongtian Yang, Liang Xu, Yuanhao Liang, Yuan Chen, Yancheng Li, Xiaoying Fan, Yufeng Liu
Journal of Molecular Structure
40.
Molecularly imprinted polymers for sensing/depleting human serum albumin (HSA): A critical review of recent advances and current challenges
Ali Jahanban-Esfahlan, Ryszard Amarowicz
International Journal of Biological Macromolecules
Ali Jahanban-Esfahlan, Ryszard Amarowicz
International Journal of Biological Macromolecules
41.
Interaction mechanism and compatibility studies of silk protein peptide (SPP) with the common surfactants SDS and DTAB
Qian Zhang, Xinru Zhang, Yaxuan Qi, Yutong Li, Yu Guo, Hanlu Jiang, Yanrong Chen, Jie Liu
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Qian Zhang, Xinru Zhang, Yaxuan Qi, Yutong Li, Yu Guo, Hanlu Jiang, Yanrong Chen, Jie Liu
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
42.
A comprehensive investigation of the nano-[Cu2-(DIP)2-EA] effects on HSA through spectroscopic procedures and computer simulations
Nahid Shahabadi, Lida Ghaffari
Heliyon
Nahid Shahabadi, Lida Ghaffari
Heliyon
43.
Inhibitory effect of caffeic acid and dihydrocaffeic acid on the formation of advanced glycation end products: Mechanism analysis based on intermolecular interaction
Yanqing Zhang, Lixia Yuan, Qiulu Wang, Xuejie Zhang, Yiyun Yang, Min Liu
Journal of Molecular Liquids
Yanqing Zhang, Lixia Yuan, Qiulu Wang, Xuejie Zhang, Yiyun Yang, Min Liu
Journal of Molecular Liquids
44.
Dairy and nondairy proteins as nano‐architecture structures for delivering phenolic compounds: Unraveling their molecular interactions to maximize health benefits
Cristine Couto de Almeida, Diego dos Santos Baião, Davi Vieira Teixeira da Silva, Lucileno Rodrigues da Trindade, Patricia Ribeiro Pereira, Carlos Adam Conte‐Junior, Vania Margaret Flosi Paschoalin
Comprehensive Reviews in Food Science and Food Safety
Cristine Couto de Almeida, Diego dos Santos Baião, Davi Vieira Teixeira da Silva, Lucileno Rodrigues da Trindade, Patricia Ribeiro Pereira, Carlos Adam Conte‐Junior, Vania Margaret Flosi Paschoalin
Comprehensive Reviews in Food Science and Food Safety
| eISSN: | 2083-6007 |
| ISSN: | 1230-0322 |
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