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Oral Supplementation with Three Vegetable Oils Differing in Fatty Acid Composition Alleviates High-Fat Diet-Induced Obesity in Mice by Regulating Inflammation and Lipid Metabolism
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College of Food Science, Southwest University, Beibei District, Chongqing 400715, P.R. China
Food Science and Technology Department, Faculty of Agriculture, Al-Azhar University (Assiut Branch), Assiut, Egypt
Chongqing Academy of Agricultural Science, Chongqing 400060, P.R. China
Science and Technology Department, Chongqing Medical and Pharmaceutical College, Chongqing 401334, P.R. China
Chongqing Key Laboratory of Specialty Food Co-Built by Sichuan and Chongqing, Chongqing 400715, P.R. China
Submission date: 2022-12-03
Acceptance date: 2023-02-02
Online publication date: 2023-02-28
Publication date: 2023-02-28
Corresponding author
Geng Zhong   

Food Science, College of Food Science, Southwest University, 400715, Chongqing, China
Pol. J. Food Nutr. Sci. 2023;73(1):80-94
Obesity has become one of the most prevalent chronic diseases worldwide, which affects people's health and daily lives. Therefore, this study aimed to investigate the anti-obesity effects of perilla seed oil (PSO), sunflower oil (SFO), and tea seed oil (TSO) and their potential mechanisms in mice fed a high-fat diet (HFD). Mice were divided into five groups: ND, mice fed a normal diet; HFD, mice fed a high-fat diet; PSO, SFO, and TSO, mice fed a high-fat diet supplemented with PSO, SFO, and TSO at 2 g/kg body weight per day, respectively. Our findings showed that oral supplementation with all three oils for 8 weeks significantly reduced body weight, tissue weight, insulin resistance index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and free fatty acids (FFA), and markedly alleviated hyperglycemia, hyperlipidemia, and hepatic steatosis in obese mice. It also decreased leptin, pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and (IL)-1beta (IL-1β), and increased anti-inflammatory adipokine adiponectin at both secretion and mRNA expression levels in the epididymal adipose tissue (EAT). Moreover, PSO, SFO, and TSO administration increased the expression levels of fatty acid β-oxidation-related genes, including peroxisome proliferator-activated receptor-alpha (PPAR-α), carnitine palmitoyltransferase 1a (CPT1a) and CPT1b, and thermogenesis-related genes such as uncoupling protein 1 (UCP1), and decreased the expression levels of lipid synthesis-related genes, including fatty acid synthase (FAS) and PPAR-γ in EAT. In conclusion, PSO, SFO, and TSO supplementation could have potential anti-obesity effects in HFD-fed mice by reducing inflammation and improving lipid metabolism.
This work was financially supported by the Chongqing Modern Mountainous Characteristic Efficient Agricultural Industrial Technology System (Innovation Team No. 2021 [4]); Key R&D projects of Sichuan Science and Technology Plan (2020YFN0148).
The authors declare no conflict of interest
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