The aim of the present study was to evaluate effects of enriching the uncorrected diet of post-mastectomy women with a hull-less oat Akt cultivar on the subjects’ blood glucose, triacylglycerol, total cholesterol, HDL- and LDL-cholesterol, fibrinogen, and estradiol levels. The cholesterols were assayed in a closed system, with Roche reagents in an Integra biochemical analyser. The fibrinogen level was determined, following clotting, with a Behring BCT DADE, while estradiol was assayed by chemoluminescence in a DPC Immulite instrument. The subjects consumed oat grains 3 times a week, for 4 months, at amounts contributing 10-15% to the diet’s energy content. Whenever consumed, oats replaced a carbohydrate product usually eaten during a meal (e.g. bread for breakfast, lunch or dinner, or potatoes, grits, rice, pasta etc. for lunch or dinner). The oat enrichment was found to produce a statistically significant (P<0.01) reduction in the glucose (from 98 to 90 mg/dL) and HDL-cholesterol (from 59.3 to 55.9 mg/dL) levels as well as a significant (P<0.01) increase in the fibrinogen concetration (from 280 to 361 mg/dL). The post-hysterectomy women showed a significant (P<0.05) increase in the blood estradiol level (from 10.0 to 19.5 pg/mL). Changes in triacylglycerol (from 126 to 130 mg/dL), total cholesterol (from 206 to 202 mg/dL), and LDL-cholesterol (from 122 to 115 mg/dL) levels as well as those of estradiol (from 62 to 290 pg/mL) in those subjects with intact ovaries were in significant.