IN VIVO EVALUATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF DIFFERENT EXTRACTS OF DATE FRUITS IN ADJUVANT ARTHRITIS.
 
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Pol. J. Food Nutr. Sci. 2004;54(4):397–402
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ABSTRACT
This study was carried out to evaluate the antioxidant and anti-inflammatory activity of methanolic and water extracts of the edible portion of date fruits (Phoenix dactylifera L., Family Palmae) and methanolic extract of date seeds in adjuvant arthritis in rats, a model of chronic inflammation. Acute oral toxicity of the different extracts was carried out to determine their safety as functional foods. The results revealed that oral administration of the methanolic and aqueous extracts of edible portion of date fruits suppressed the swelling in the foot significantly by 67.8 and 61.3% respectively, while the methanolic extract of date seeds showed significant reduction by 35.5%. Antioxidant state (plasma vitamin C, E and A and b-carotene) increased significantly on administration of different extracts, while plasma level of MDA reduced significantly. Methanolic extract of edible portion of the fruit was the best in reducing foot swelling, ESR and plasma fibrinogen and in normalizing the plasma level of antioxidants. Adjuvant arthritic rats showed significant reduction in body weight gain and food efficiency ratio. Administration of any of the extracts produced significant increase in body weight gain and food efficiency ratio. Acute lethal toxicity test showed that the safest extract was the methanolic of edible portion of the fruit followed by the water extract that showed complete safety up to 6 g/kg mice weight. Methanolic extract of the seed showed LD50 equal to 6.75 g/kg mice.
ISSN:1230-0322