EFFECT OF HIGH-FAT DIETS WITH DIFFERENT FATTY ACID COMPOSITION ON HEPATIC 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVITY IN RATS
 
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Pol. J. Food Nutr. Sci. 2006;56(Special issue 2s):25–28
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ABSTRACT
Recent studies suggest a key role for tissue aberrant expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and for tissue glucocorticoid excess in dysregulation of metabolism observed in diabetes and other metabolic disorders linked to central obesity. In an experiment carried out in 50 adult Wistar rats fed on diets containing sunflower oil, rapeseed oil, lard or cod liver oil at two levels (20 and 40% w/w), we were the first to show a beneficial inhibitory effect of all fats but one (sunflower oil) on hepatic 11β-HSD1 activity, given the moderately high consumption of fat (i.e. 20%).
ISSN:1230-0322